Evaluation of individual symptoms cannot predict presence of gastric hypersensitivity in functional dyspepsia

Recently, the concept of gastric hypersensitivity was introduced as an important factor in the pathophysiology of functional dyspepsia (FD), but it is unclear which symptoms can predict the presence of gastric hypersensitivity. Therefore, we evaluated the relationship between common symptoms of FD a...

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Bibliographic Details
Published in:Digestive diseases and sciences 2000-08, Vol.45 (8), p.1680-1684
Main Authors: RHEE, Poong-Lyul, KIM, Young-Ho, HEE JUNG SON, KIM, Jae J, KWANG CHEUL KOH, SEUNG WOON PAIK, JONG CHUL RHEE, KYOO WAN CHOI
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Dyspepsia - etiology
Dyspepsia - physiopathology
Female
Gastric Emptying - physiology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical sciences
Middle Aged
Nausea
Other diseases. Semiology
Stomach - physiopathology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Vomiting
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Summary:Recently, the concept of gastric hypersensitivity was introduced as an important factor in the pathophysiology of functional dyspepsia (FD), but it is unclear which symptoms can predict the presence of gastric hypersensitivity. Therefore, we evaluated the relationship between common symptoms of FD and various parameters measured by gastric barostat in FD patients. Gastric barostat tests were performed in 64 FD patients and 20 healthy control subjects without gastrointestinal symptoms. Individual symptoms such as early satiety, postprandial fullness, sense of delayed emptying, nausea, vomiting, and epigastric soreness were collected and graded as mild to severe. Basal tone, gastric compliance, and postprandial receptive relaxation were similar in controls and patients, the threshold of abdominal discomfort was lower in FD patients than in controls (8.9 +/- 3.6 mm Hg and 14.5 +/- 3.7 mm Hg, respectively, P < 0.05). However, there were no significant differences in the threshold of abdominal discomfort according to the severity of individual symptoms. In conclusion, a simple evaluation of individual symptoms could not predict the presence of gastric hypersensitivity.
ISSN:0163-2116
1573-2568
DOI:10.1023/A:1005550019308