Improvement of early functional atherosclerotic changes in males with hypercholesterolemia after vitamin E supplementation

Vitamin E as an antioxidant vitamin reduces the susceptibility of low-density lipoprotein (LDL) cholesterol to oxidation and may have antiatherosclerotic effects. We tested the hypothesis that six months of 400 mg vitamin E supplementation favourably affects early functional changes in atherosclerot...

Full description

Saved in:
Bibliographic Details
Published in:Pflügers Archiv 2000, Vol.440 (5 Suppl), p.R126-R128
Main Authors: Borovnicar, A, Keber, I, Stavljenić Rukavina, A, Yaletel Kragelj, L
Format: Article
Language:English
Subjects:
Adult
Arteriosclerosis - complications
Arteriosclerosis - drug therapy
Arteriosclerosis - physiopathology
Brachial Artery - diagnostic imaging
Brachial Artery - drug effects
Brachial Artery - physiopathology
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiopathology
Humans
Hypercholesterolemia - complications
Hyperemia - diagnostic imaging
Hyperemia - etiology
Hyperemia - physiopathology
Male
Middle Aged
Nitroglycerin - therapeutic use
Ultrasonography
Vasodilation
Vasodilator Agents - therapeutic use
Vitamin E - therapeutic use
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Vitamin E as an antioxidant vitamin reduces the susceptibility of low-density lipoprotein (LDL) cholesterol to oxidation and may have antiatherosclerotic effects. We tested the hypothesis that six months of 400 mg vitamin E supplementation favourably affects early functional changes in atherosclerotic process in subjects with hypercholesterolemia. The diameter of the brachial artery at rest, after reactive hyperemia (representing endothelium-dependent vasodilatation) and after sublingual glyceryl-trinitrate (representing endothelium-independent vasodilatation), were determined by ultrasonographic method (B mode) before and after the intervention period. After the intervention period the brachial endothelium-dependent vasodilatation increased significantly in the vitamin E group while it did not change in the placebo group. In conclusion, six months of oral vitamin E supplementation results in improvement of the endothelium-dependent vasodilatation in men with hypercholesterolemia.
ISSN:0031-6768
1432-2013
DOI:10.1007/s004240000032