oxygenated chalcones and bischalcones as potential antimalarial agents

Oxygenated chalcones ( 3a, b) and bischalcones ( 4a– j) have been synthesized and evaluated for antimalarial activity against chloroquine sensitive and resistant strains of Plasmodium berghei in mice. Some of the screened compounds, 3a, 4c, 4e, 4f and 4i, have shown significant activity at 100 mg/kg...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2000-10, Vol.10 (19), p.2159-2161
Main Authors: Ram, Vishnu J, Saxena, Abhishek S, Srivastava, Shalini, Chandra, Subhash
Format: Article
Language:English
Subjects:
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimalarials - chemical synthesis
Antimalarials - chemistry
Antimalarials - therapeutic use
Antiparasitic agents
Biological and medical sciences
Chalcone - analogs & derivatives
Chalcone - chemical synthesis
Chalcone - chemistry
Chalcone - therapeutic use
Chloroquine - pharmacology
Drug Design
Drug Resistance
Malaria - drug therapy
Malaria - parasitology
Male
Medical sciences
Mice
Molecular Structure
Pharmacology. Drug treatments
Plasmodium berghei - drug effects
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Summary:Oxygenated chalcones ( 3a, b) and bischalcones ( 4a– j) have been synthesized and evaluated for antimalarial activity against chloroquine sensitive and resistant strains of Plasmodium berghei in mice. Some of the screened compounds, 3a, 4c, 4e, 4f and 4i, have shown significant activity at 100 mg/kg dose against sensitive strain.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)00409-1