p120 expression provides a reliable indication of the rapidity of cell duplication in cancer cells independently of tumour origin

• Published in: The Journal of pathology 2000-10, Vol.192 (2), p.216-220
• Main Authors: Trerè, Davide, Migaldi, Mario, Montanaro, Lorenzo, Pession, Annalisa, Derenzini, Massimo
• Format: Article
• Language: English
• Subjects: AgNOR proteins; Antibodies, Monoclonal; Biological and medical sciences; Blotting, Western; cancer cells; Cell Division; cell-cycle time; Densitometry; Female; Humans; Image Cytometry; immunocytochemistry; Investigative techniques, diagnostic techniques (general aspects); Luminescent Measurements; Male; Medical sciences; Miscellaneous. Technology; Neoplasm Proteins - metabolism; Neoplasms - metabolism; Neoplasms - pathology; Nuclear Proteins - metabolism; p120 protein; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Regression Analysis; Time Factors; tRNA Methyltransferases; Tumor Cells, Cultured; western blot
• ISSN: 0022-3417; 1096-9896
• DOI: 10.1002/1096-9896(2000)9999:9999<::AID-PATH695>3.0.CO;2-L

p120 is a nucleolar protein that has been immunocytochemically detected in rapidly proliferating cells of a variety of human malignancies. In the present study, the relationship between p120 expression and the rapidity of cell proliferation was evaluated in 48 human tumours of different origins. The cell proliferation rate of cancer cells was determined by quantitative analysis of AgNOR proteins. p120 immunostaining and AgNOR protein quantity were measured by image cytometry and a highly significant correlation was found between the two variables, as evaluated by linear regression analysis (r=0.98, p