Effect of atorvastatin treatment on lipoprotein lipase mass in the pre-heparin plasma in Japanese hyperlipidemic subjects

Background: Atorvastatin is a recently introduced statin that lowers LDL-cholesterol (LDL-C) and triglycerides more than some of the older statins. Methods: Twenty-one Japanese hyperlipidemic subjects were treated with atorvastatin (10 mg/day) for 6 weeks. Plasma lipid concentrations and pre-heparin...

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Bibliographic Details
Published in:Clinica chimica acta 2001-12, Vol.314 (1), p.261-264
Main Authors: Kobayashi, Junji, Maruyama, Tokiko, Masuda, Mizue, Shinomiya, Masaki
Format: Article
Language:English
Subjects:
Aged
Apolipoproteins B - metabolism
Apolipoproteins E - metabolism
Atorvastatin
Atorvastatin treatment
Biological and medical sciences
Blood Glucose - metabolism
Cross-Over Studies
Female
General and cellular metabolism. Vitamins
Heptanoic Acids - therapeutic use
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Hyperlipidemias - drug therapy
Hyperlipidemias - enzymology
Lipoprotein Lipase - blood
Lipoprotein lipase mass
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Pre-heparin plasma
Pyrroles - therapeutic use
Triglycerides - blood
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Summary:Background: Atorvastatin is a recently introduced statin that lowers LDL-cholesterol (LDL-C) and triglycerides more than some of the older statins. Methods: Twenty-one Japanese hyperlipidemic subjects were treated with atorvastatin (10 mg/day) for 6 weeks. Plasma lipid concentrations and pre-heparin plasma LPL mass before and after oral administration were evaluated using an open crossover trial format. LPL mass in the pre-heparin plasma was measured by a sandwich enzyme immunoassay. Results: Atorvastatin decreased plasma triglyceride (TG) concentration (−21%, p
ISSN:0009-8981
1873-3492
DOI:10.1016/S0009-8981(01)00701-X