Acardius or "twin-reversed arterial prefusion" sequence. Report of four cases and review of current therapeutic possibilities

We describe four cases of acardius (one of hemiacardius, two of holoacardius acephalus, and one of the holacardius amorphus) and present the current range of therapeutic possibilities: control of amniotic fluid by repeated amniocentesis or indomethacin therapy, administration of digoxin to the mothe...

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Bibliographic Details
Published in:Der Pathologe 2000-07, Vol.21 (4), p.308-314
Main Authors: Sergi, C, Grischke, E M, Schnabel, P A, Sippel, F, Adam, S, Krempien, B, Otto, H F
Format: Article
Language:ger
Subjects:
Abnormalities, Multiple - pathology
Abnormalities, Multiple - therapy
Adult
Diseases in Twins
Female
Fetofetal Transfusion - pathology
Fetofetal Transfusion - therapy
Fetus - abnormalities
Humans
Pregnancy
Pregnancy, Multiple
Twins, Monozygotic
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Summary:We describe four cases of acardius (one of hemiacardius, two of holoacardius acephalus, and one of the holacardius amorphus) and present the current range of therapeutic possibilities: control of amniotic fluid by repeated amniocentesis or indomethacin therapy, administration of digoxin to the mother, selective preterm delivery of the acardiac twin by hysterotomy, interruption of the anastomoses by injection of thrombogenic coils, sclerosing agents, umbilical cord ligation, fetoscopic laser coagulation, and thermocoagulation.
ISSN:0172-8113