Hemolipodialysis Attenuates Oxidative Stress and Removes Hydrophobic Toxins

: Uremic patients undergoing hemodialysis often have increased oxidant stress and accumulation of uremic toxins. Hemodialysis, per se, often can exacerbate oxidant stress and may be inefficient at removing hydrophobic or protein bound toxins. We describe a new hemodialytic method that incorporates l...

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Bibliographic Details
Published in:Artificial organs 2000-09, Vol.24 (9), p.685-690
Main Authors: Wratten, Mary Lou, Sereni, Luisa, Tetta, Ciro
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants - therapeutic use
Ascorbic acid
Ascorbic Acid - therapeutic use
Bilirubin
Bilirubin - blood
Blood Proteins - chemistry
Cattle
Extracorporeal Circulation
Free Radical Scavengers - therapeutic use
Free radicals
Hemodialysis
Humans
Liposomes - therapeutic use
Malondialdehyde - blood
Oxidation-Reduction
Oxidative Stress - physiology
Phosphatidylcholines - therapeutic use
Phospholipids - therapeutic use
Platelet activating factor
Platelet Activating Factor - chemistry
Renal Dialysis - instrumentation
Renal Dialysis - methods
Serum Albumin, Bovine - chemistry
Toxins, Biological - blood
Uremia - blood
Uremia - therapy
Vitamin E - therapeutic use
α-tocopherol
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Summary:: Uremic patients undergoing hemodialysis often have increased oxidant stress and accumulation of uremic toxins. Hemodialysis, per se, often can exacerbate oxidant stress and may be inefficient at removing hydrophobic or protein bound toxins. We describe a new hemodialytic method that incorporates liposomes and antioxidants to remove hydrophobic/uremic toxins and minimize free radical mediated damage. In vitro experiments measured advanced oxidation protein products (AOPP), malonaldehyde, reactive carbonyls, and the removal of platelet activating factor (PAF) and bilirubin during extracorporeal circulation with or without liposomes. We observed a significant reduction of oxidation products as well as a significant removal of PAF and bilirubin compared to normal hemodialysis.
ISSN:0160-564X
1525-1594
DOI:10.1046/j.1525-1594.2000.06626.x