Relationship of tumoral hyaluronic acid and cathepsin D contents with histological type of gastric carcinoma

The aim of this work was to evaluate the cytosolic contents of hyaluronic acid (HA) and cathepsin D (CatD) in gastric carcinomas and their possible relationships with the clinicopathological parameters of the tumors. Our study demonstrated a wide variability in the cytosolic levels of HA (mean +/- S...

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Published in:The International journal of biological markers 2000-07, Vol.15 (3), p.215-218
Main Authors: GARCIA, I, VIZOSO, F, SUAREZ, C, SANZ, L, RODRIGUEZ, J. C, ROIZ, C, GARCIA-MUNIZ, J. L
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cathepsin D - analysis
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hyaluronic Acid - analysis
Male
Medical sciences
Middle Aged
Stomach Neoplasms - chemistry
Stomach Neoplasms - pathology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:The aim of this work was to evaluate the cytosolic contents of hyaluronic acid (HA) and cathepsin D (CatD) in gastric carcinomas and their possible relationships with the clinicopathological parameters of the tumors. Our study demonstrated a wide variability in the cytosolic levels of HA (mean +/- SEM: 3748 +/- 411 ng/mg protein) and cathepsin D (52 +/- 4 pmol/mg protein) in the tumors of 78 gastric cancer patients. In addition, the tumoral contents of HA and CatD were significantly higher (p
ISSN:0393-6155
1724-6008
DOI:10.1177/172460080001500302