Macharistol, a New Cytotoxic Cinnamylphenol from the Stems of Machaerium aristulatum

A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive cons...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2001-11, Vol.64 (11), p.1483-1485
Main Authors: SEO, Eun-Kyoung, KIM, Nam-Cheol, MI, Qiuwen, CHAI, Heebyung, WALL, Monroe E., WANI, Mansukh C., NAVARRO, Hernán A., BURGESS, Jason P., GRAHAM, James G., CABIESES, Fernando, TAN, Ghee T., FARNSWORTH, Norman R., PEZZUTO, John M., KINGHORN, A. Douglas
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Benzopyrans - chemistry
Benzopyrans - isolation & purification
Benzopyrans - pharmacology
Biological and medical sciences
Fabaceae - chemistry
General pharmacology
Humans
Isoflavones - chemistry
Isoflavones - isolation & purification
Isoflavones - pharmacology
Medical sciences
Molecular Structure
Nasopharyngeal Neoplasms
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenols - chemistry
Phenols - isolation & purification
Phenols - pharmacology
Plant Stems - chemistry
Plants, Medicinal - chemistry
Pterocarpans
Structure-Activity Relationship
Tumor Cells, Cultured - drug effects
Tumor Cells, Cultured - enzymology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0103158