Bactericidal activity of normal cord serum (NCS) against Gram-negative rods with sialic acid-containing lipopolysaccharides (LPS)

Abstract Sialic acids, that are important constituents of animal tissue glycoconjugates, are also present in antigens of some bacterial strains. Capsular polysaccharides with sialic acid have been extensively studied whereas little is known on lipopolysaccharides which contain sialic acid. The susce...

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Bibliographic Details
Published in:FEMS immunology and medical microbiology 2001-10, Vol.31 (3), p.169-173
Main Authors: Mielnik, Gabriela, Gamian, Andrzej, Doroszkiewicz, Włodzimierz
Format: Article
Language:English
Subjects:
Acids
Animal tissues
Antigens
Baby foods
Bactericidal activity
Bacteriolysis
Biological and medical sciences
Blood Bactericidal Activity
Capsular polysaccharides
Carbohydrate Sequence
Enterobacteriaceae - chemistry
Enterobacteriaceae - growth & development
Enterobacteriaceae - immunology
Fetal Blood - immunology
Fundamental and applied biological sciences. Psychology
Glycoconjugates
Humans
Infant, Newborn
Lipopolysaccharide
Lipopolysaccharides
Lipopolysaccharides - chemistry
Microbiology
Molecular Sequence Data
N-Acetylneuraminic Acid - analysis
Neonates
Polysaccharides
Saccharides
Serum killing
Sialic acid
Sialic acids
Strains (organisms)
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Summary:Abstract Sialic acids, that are important constituents of animal tissue glycoconjugates, are also present in antigens of some bacterial strains. Capsular polysaccharides with sialic acid have been extensively studied whereas little is known on lipopolysaccharides which contain sialic acid. The susceptibility of Gram-negative strains with sialic acid-containing lipopolysaccharides to the bactericidal action of the sera of newborns was examined. The strains investigated showed variable sensitivity to the bactericidal action of normal cord serum.
ISSN:0928-8244
1574-695X
2049-632X
DOI:10.1111/j.1574-695X.2001.tb00516.x