Evaluation of thin-layer methods in urine cytology

Evaluation of thin‐layer methods in urine cytology Conventional cytospin smears prepared from urinary tract specimens were compared with two new thin layer techniques, i.e. ThinPrep® and AutoCyte PREP™. Cellularity, cell preservation, background features, detection rate, screening time and ease of p...

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Bibliographic Details
Published in:Cytopathology (Oxford) 2001-10, Vol.12 (5), p.306-313
Main Authors: Wright, R. G., Halford, J. A.
Format: Article
Language:English
Subjects:
AutoCyte PREP
Carcinoma, Transitional Cell - pathology
Carcinoma, Transitional Cell - urine
Clinical Laboratory Techniques
Community Health Services
Cytodiagnosis - instrumentation
Cytodiagnosis - methods
cytology
Humans
thin-layer techniques
ThinPrep
Urinary Tract - pathology
urinary tract specimens
Urine - cytology
Urologic Diseases - pathology
Urologic Diseases - urine
Urologic Neoplasms - pathology
Urologic Neoplasms - urine
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Summary:Evaluation of thin‐layer methods in urine cytology Conventional cytospin smears prepared from urinary tract specimens were compared with two new thin layer techniques, i.e. ThinPrep® and AutoCyte PREP™. Cellularity, cell preservation, background features, detection rate, screening time and ease of preparation were evaluated. Thin‐layer techniques when applied to urine cytology were found to improve cell yield and cell preservation, and reduce background artefact. The reporting rate for abnormal urothelial cells was comparable to conventional cytospin smears, as was screening time. Laboratory staff found the methodologies to be practicable and easily incorporated into a large routine diagnostic service. We conclude that a one‐slide thin‐layer urine preparation is comparable to four cytospin slides in the detection of urothelial abnormalities, and that both ThinPrep® and AutoCyte PREP™ have comparable features.
ISSN:0956-5507
1365-2303
DOI:10.1046/j.1365-2303.2001.00341.x