A Synthetic Transmembrane Polyether Model Active in Lipid Bilayers

A model polyether-based ion channel-like compound was rationally designed and synthesized. Macromolecules 1c−f were incorporated into phospholipid vesicles and shown to facilitate the transmembrane sodium transport.

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Bibliographic Details
Published in:Organic letters 2000-10, Vol.2 (20), p.3161-3164
Main Authors: Espínola, Carmen G, Pérez, Ricardo, Martín, Julio D
Format: Article
Language:English
Subjects:
Alkenes - chemical synthesis
Alkenes - chemistry
Ethers - chemical synthesis
Ethers - chemistry
Lipid Bilayers - chemistry
Membranes, Artificial
Models, Molecular
Polymers - chemical synthesis
Polymers - chemistry
Potassium Channels - chemistry
Protein Conformation
Sodium Radioisotopes
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Description
Summary:A model polyether-based ion channel-like compound was rationally designed and synthesized. Macromolecules 1c−f were incorporated into phospholipid vesicles and shown to facilitate the transmembrane sodium transport.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0063555