Folate, DNA methylation, and gene expression: factors of nature and nurture

Jacob discusses a study that shows an effect of folate deficiency on methylation of lymphocyte DNA in healthy elderly women. The findings confirm and extend previous research showing that lack of folate or methyl group nutrients in the diet may cause DNA hypomethylation in both rats and humans.

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Bibliographic Details
Published in:The American journal of clinical nutrition 2000-10, Vol.72 (4), p.903-904
Main Author: Jacob, R A
Format: Article
Language:English
Subjects:
Congenital Abnormalities - prevention & control
Deoxyribonucleic acid
Diet
DNA
DNA Methylation
Female
Folic Acid - metabolism
Folic Acid - physiology
Folic Acid Deficiency - pathology
Gene Expression Regulation
Genes
Health
Humans
Neoplasms - etiology
Nutrition
Older people
Vitamin B
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Description
Summary:Jacob discusses a study that shows an effect of folate deficiency on methylation of lymphocyte DNA in healthy elderly women. The findings confirm and extend previous research showing that lack of folate or methyl group nutrients in the diet may cause DNA hypomethylation in both rats and humans.
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/72.4.903