Antifungal monoterpene production in elicited cell suspension cultures of Piqueria trinervia

Cell suspension cultures of the traditional medicinal plant Piqueria trinervia Cav., which synthesizes monoterpene piquerol A, were established. A defense response was induced in the cultures when eight homogenized fungi isolated from wild populations of P. trinervia were added. Piquerol A was not p...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2000-09, Vol.55 (1), p.51-57
Main Authors: Saad, Isabel, Dı́az, Eduardo, Chávez, Isabel, Reyes-Chilpa, Ricardo, Rubluo, Abraham, Jiménez-Estrada, Manuel
Format: Article
Language:English
Subjects:
2-Methylene-7,7-dimethylbicyclo heptane-4,6-diol
Antifungal activity
Antifungal Agents - chemistry
Antifungal Agents - metabolism
Asteraceae
Asteraceae - chemistry
Asteraceae - cytology
Biological and medical sciences
Cells, Cultured
Elicitors
Fundamental and applied biological sciences. Psychology
Fungal plant pathogens
Metabolism
Metabolism. Physicochemical requirements
Molecular Structure
Monoterpenes
Pathology, epidemiology, host-fungus relationships. Damages, economic importance
Phytopathogenic fungi
Phytopathology. Animal pests. Plant and forest protection
Piqueria trinervia
Piquerinol
Plant physiology and development
Plant tissue cultures
Secondary metabolites
Spectrum Analysis
Terpenes - chemistry
Terpenes - metabolism
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Summary:Cell suspension cultures of the traditional medicinal plant Piqueria trinervia Cav., which synthesizes monoterpene piquerol A, were established. A defense response was induced in the cultures when eight homogenized fungi isolated from wild populations of P. trinervia were added. Piquerol A was not produced in the elicited system, while four other substances were synthesized de novo. They were excreted into the medium and inhibited in vitro fungal growth. The most abundant substance produced in this system was a new monoterpene: 2-methylene-7,7-dimethylbicyclo (3,3,1) heptane-4,6-diol. Monoterpenes in the cell suspension culture reported here were produced via two metabolic channels: the first acted constitutively and expressed in liquid and solid cultures, the second is inducible in response to several pathogens and elicitor substances.
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(00)00211-9