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Elevated nitric oxide metabolite levels in chronic sinusitis

Decreased exhaled nitric oxide (NO) is found in chronic sinusitis. NO metabolites (nitrates, nitrites, and S-nitrosothiols) were measured in sinus lavages with a rabbit model of chronic sinusitis. NO metabolite levels (mean ± SD) were 3.0 ± 1.6 μmol/L in uninfected rabbits, 10.7 ± 11.4 μmol/L in inf...

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Published in:	Otolaryngology-head and neck surgery 2000-10, Vol.123 (4), p.357-362
Main Authors:	Schlosser, Rodney J., Spotnitz, William D., Peters, Edward J., Fang, Kezhong, Gaston, Benjamin, Gross, Charles W.
Format:	Article
Language:	English
Subjects:	Animals Chronic Disease Disease Models, Animal Microscopy, Electron, Scanning Mucociliary Clearance Nasal Mucosa - metabolism Nasal Mucosa - microbiology Nasal Mucosa - ultrastructure Nitric Oxide - analysis Nitric Oxide - metabolism Pneumococcal Infections - physiopathology Rabbits Reference Values Severity of Illness Index Sinusitis - metabolism Sinusitis - physiopathology
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container_title	Otolaryngology-head and neck surgery
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creator	Schlosser, Rodney J. Spotnitz, William D. Peters, Edward J. Fang, Kezhong Gaston, Benjamin Gross, Charles W.
description	Decreased exhaled nitric oxide (NO) is found in chronic sinusitis. NO metabolites (nitrates, nitrites, and S-nitrosothiols) were measured in sinus lavages with a rabbit model of chronic sinusitis. NO metabolite levels (mean ± SD) were 3.0 ± 1.6 μmol/L in uninfected rabbits, 10.7 ± 11.4 μmol/L in infected animals, and 7.6 ± 5.4 μmol/L in postantrostomy recovering animals. Infected sinuses had elevated levels of NO metabolites that were statistically significant ( P < 0.01) when compared with uninfected sinuses. Mucociliary transport velocity was measured in uninfected (16.0 ± 5.7 mm/minute), infected (5.2 ± 1.3 mm/minute), and recovery phases (3.0 mm/ minute). Endoscopic appearance, light and electron microscopy, and bacterial cultures improved during recovery. Elevated levels of NO metabolites were found during chronic sinusitis and began to return to normal levels during recovery. The possible link between NO in epithelial autotoxicity and host defense mechanisms warrants further investigation. (Otolaryngol Head Neck Surg 2000;123:357-62.)
doi_str_mv	10.1067/mhn.2000.107405
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NO metabolites (nitrates, nitrites, and S-nitrosothiols) were measured in sinus lavages with a rabbit model of chronic sinusitis. NO metabolite levels (mean ± SD) were 3.0 ± 1.6 μmol/L in uninfected rabbits, 10.7 ± 11.4 μmol/L in infected animals, and 7.6 ± 5.4 μmol/L in postantrostomy recovering animals. Infected sinuses had elevated levels of NO metabolites that were statistically significant ( P < 0.01) when compared with uninfected sinuses. Mucociliary transport velocity was measured in uninfected (16.0 ± 5.7 mm/minute), infected (5.2 ± 1.3 mm/minute), and recovery phases (3.0 mm/ minute). Endoscopic appearance, light and electron microscopy, and bacterial cultures improved during recovery. Elevated levels of NO metabolites were found during chronic sinusitis and began to return to normal levels during recovery. The possible link between NO in epithelial autotoxicity and host defense mechanisms warrants further investigation. 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(Otolaryngol Head Neck Surg 2000;123:357-62.)</description><subject>Animals</subject><subject>Chronic Disease</subject><subject>Disease Models, Animal</subject><subject>Microscopy, Electron, Scanning</subject><subject>Mucociliary Clearance</subject><subject>Nasal Mucosa - metabolism</subject><subject>Nasal Mucosa - microbiology</subject><subject>Nasal Mucosa - ultrastructure</subject><subject>Nitric Oxide - analysis</subject><subject>Nitric Oxide - metabolism</subject><subject>Pneumococcal Infections - physiopathology</subject><subject>Rabbits</subject><subject>Reference Values</subject><subject>Severity of Illness Index</subject><subject>Sinusitis - metabolism</subject><subject>Sinusitis - physiopathology</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNo1kM9LwzAUx4Mobk7P3qQnb515Sdos4EXG_AEDL3oObfLKIm06m3Tof29G5-nx3vfDg--HkFugS6ClfOh2fskoPW5S0OKMzIEqmZcrkOdkTkGJvFBqNSNXIXwlriylvCQzAMoolKs5edy0eKgi2sy7ODiT9T_OYtZhrOq-dRGzlGMbMuczsxt6n5Dg_BhcdOGaXDRVG_DmNBfk83nzsX7Nt-8vb-unbY6skDGXFUiLjKOgHJmSCMoWxpRQs8pySY0xrGl4YwRvhCgabqlKRy5sU4gaCr4g99Pf_dB_jxii7lww2LaVx34MWjIOIKRK4N0JHOsOrd4PrquGX_3fNwFqAlIlPDgcdDAOvUHrBjRR295poProVie3-uhWT275H8rUavo</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Schlosser, Rodney J.</creator><creator>Spotnitz, William D.</creator><creator>Peters, Edward J.</creator><creator>Fang, Kezhong</creator><creator>Gaston, Benjamin</creator><creator>Gross, Charles W.</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20001001</creationdate><title>Elevated nitric oxide metabolite levels in chronic sinusitis</title><author>Schlosser, Rodney J. ; Spotnitz, William D. ; Peters, Edward J. ; Fang, Kezhong ; Gaston, Benjamin ; Gross, Charles W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e257t-7a17de23e403e297e19d5cc61b2ad370ccc2ff3fc43f445f3d090cc34df54b153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Chronic Disease</topic><topic>Disease Models, Animal</topic><topic>Microscopy, Electron, Scanning</topic><topic>Mucociliary Clearance</topic><topic>Nasal Mucosa - metabolism</topic><topic>Nasal Mucosa - microbiology</topic><topic>Nasal Mucosa - ultrastructure</topic><topic>Nitric Oxide - analysis</topic><topic>Nitric Oxide - metabolism</topic><topic>Pneumococcal Infections - physiopathology</topic><topic>Rabbits</topic><topic>Reference Values</topic><topic>Severity of Illness Index</topic><topic>Sinusitis - metabolism</topic><topic>Sinusitis - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schlosser, Rodney J.</creatorcontrib><creatorcontrib>Spotnitz, William D.</creatorcontrib><creatorcontrib>Peters, Edward J.</creatorcontrib><creatorcontrib>Fang, Kezhong</creatorcontrib><creatorcontrib>Gaston, Benjamin</creatorcontrib><creatorcontrib>Gross, Charles W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schlosser, Rodney J.</au><au>Spotnitz, William D.</au><au>Peters, Edward J.</au><au>Fang, Kezhong</au><au>Gaston, Benjamin</au><au>Gross, Charles W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated nitric oxide metabolite levels in chronic sinusitis</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>123</volume><issue>4</issue><spage>357</spage><epage>362</epage><pages>357-362</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>Decreased exhaled nitric oxide (NO) is found in chronic sinusitis. NO metabolites (nitrates, nitrites, and S-nitrosothiols) were measured in sinus lavages with a rabbit model of chronic sinusitis. NO metabolite levels (mean ± SD) were 3.0 ± 1.6 μmol/L in uninfected rabbits, 10.7 ± 11.4 μmol/L in infected animals, and 7.6 ± 5.4 μmol/L in postantrostomy recovering animals. Infected sinuses had elevated levels of NO metabolites that were statistically significant ( P < 0.01) when compared with uninfected sinuses. Mucociliary transport velocity was measured in uninfected (16.0 ± 5.7 mm/minute), infected (5.2 ± 1.3 mm/minute), and recovery phases (3.0 mm/ minute). Endoscopic appearance, light and electron microscopy, and bacterial cultures improved during recovery. Elevated levels of NO metabolites were found during chronic sinusitis and began to return to normal levels during recovery. The possible link between NO in epithelial autotoxicity and host defense mechanisms warrants further investigation. 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subjects	Animals Chronic Disease Disease Models, Animal Microscopy, Electron, Scanning Mucociliary Clearance Nasal Mucosa - metabolism Nasal Mucosa - microbiology Nasal Mucosa - ultrastructure Nitric Oxide - analysis Nitric Oxide - metabolism Pneumococcal Infections - physiopathology Rabbits Reference Values Severity of Illness Index Sinusitis - metabolism Sinusitis - physiopathology
title	Elevated nitric oxide metabolite levels in chronic sinusitis
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