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The Haptoglobin 2-2 Phenotype Affects Serum Markers of Iron Status in Healthy Males

Human iron status is influenced by environmental and genetic factors. We hypothesized that the genetic polymorphism of haptoglobin (Hp), a hemoglobin-binding plasma protein, could affect iron status. Reference values of serum iron status markers were compared according to Hp phenotypes (Hp 1-1, Hp 2...

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Published in:Clinical chemistry (Baltimore, Md.) Md.), 2000-10, Vol.46 (10), p.1619-1625
Main Authors: Langlois, Michel R, Martin, Marie-Elise, Boelaert, Johan R, Beaumont, Carole, Taes, Youri E, De Buyzere, Marc L, Bernard, Dirk R, Neels, Hugo M, Delanghe, Joris R
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Language:English
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Summary:Human iron status is influenced by environmental and genetic factors. We hypothesized that the genetic polymorphism of haptoglobin (Hp), a hemoglobin-binding plasma protein, could affect iron status. Reference values of serum iron status markers were compared according to Hp phenotypes (Hp 1-1, Hp 2-1, Hp 2-2; determined by starch gel electrophoresis) in 717 healthy adults. Iron storage was investigated in peripheral blood monocyte-macrophages by measuring cytosolic L- and H-ferritins and by in vitro uptake of radiolabeled ((125)I) hemoglobin-haptoglobin complexes. In males but not in females, the Hp 2-2 phenotype was associated with higher serum iron (P
ISSN:0009-9147
1530-8561
DOI:10.1093/clinchem/46.10.1619