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The Haptoglobin 2-2 Phenotype Affects Serum Markers of Iron Status in Healthy Males
Human iron status is influenced by environmental and genetic factors. We hypothesized that the genetic polymorphism of haptoglobin (Hp), a hemoglobin-binding plasma protein, could affect iron status. Reference values of serum iron status markers were compared according to Hp phenotypes (Hp 1-1, Hp 2...
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Published in: | Clinical chemistry (Baltimore, Md.) Md.), 2000-10, Vol.46 (10), p.1619-1625 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Human iron status is influenced by environmental and genetic factors. We hypothesized that the genetic polymorphism of haptoglobin (Hp), a hemoglobin-binding plasma protein, could affect iron status.
Reference values of serum iron status markers were compared according to Hp phenotypes (Hp 1-1, Hp 2-1, Hp 2-2; determined by starch gel electrophoresis) in 717 healthy adults. Iron storage was investigated in peripheral blood monocyte-macrophages by measuring cytosolic L- and H-ferritins and by in vitro uptake of radiolabeled ((125)I) hemoglobin-haptoglobin complexes.
In males but not in females, the Hp 2-2 phenotype was associated with higher serum iron (P |
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ISSN: | 0009-9147 1530-8561 |
DOI: | 10.1093/clinchem/46.10.1619 |