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Imaging of malignant infantile osteopetrosis before and after bone marrow transplantation
Malignant infantile osteopetrosis (MIOP) is a sclerosing bone disease caused by absence or defective function of osteoclasts. Since these are of haemopoietic origin, the disease can be cured by allogeneic stem-cell transplantation, but there are no detailed studies of radiological follow-up of these...
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| Published in: | Pediatric radiology 2001-12, Vol.31 (12), p.869-875 |
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| container_end_page | 875 |
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| container_title | Pediatric radiology |
| container_volume | 31 |
| creator | CHEOW, Heok K STEWARD, Colin G GRIER, David J |
| description | Malignant infantile osteopetrosis (MIOP) is a sclerosing bone disease caused by absence or defective function of osteoclasts. Since these are of haemopoietic origin, the disease can be cured by allogeneic stem-cell transplantation, but there are no detailed studies of radiological follow-up of these procedures.
To investigate the radiological findings at presentation and follow-up in children undergoing bone marrow transplantation (BMT) for MIOP.
Examination of the records and imaging studies of nine paediatric patients undergoing BMT for MIOP during 1988-2000.
Presentation findings included characteristic features such as fractures, subperiosteal new bone formation and rachitic appearances. Five children engrafted successfully, allowing assessment of the nature and speed of resolution of radiological features after transplantation.
Radiological improvement was apparent within 2 months of successful engraftment with almost complete resolution of abnormalities after 1 year. Studies in two children who are, respectively, 58 and 83 months post-transplant show complete resolution of all bone changes. |
| doi_str_mv | 10.1007/s002470100008 |
| format | article |
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To investigate the radiological findings at presentation and follow-up in children undergoing bone marrow transplantation (BMT) for MIOP.
Examination of the records and imaging studies of nine paediatric patients undergoing BMT for MIOP during 1988-2000.
Presentation findings included characteristic features such as fractures, subperiosteal new bone formation and rachitic appearances. Five children engrafted successfully, allowing assessment of the nature and speed of resolution of radiological features after transplantation.
Radiological improvement was apparent within 2 months of successful engraftment with almost complete resolution of abnormalities after 1 year. Studies in two children who are, respectively, 58 and 83 months post-transplant show complete resolution of all bone changes.</description><identifier>ISSN: 0301-0449</identifier><identifier>EISSN: 1432-1998</identifier><identifier>DOI: 10.1007/s002470100008</identifier><identifier>PMID: 11727023</identifier><identifier>CODEN: PDRYA5</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Biological and medical sciences ; Bone Marrow Transplantation ; Diseases of the osteoarticular system ; Extremities - diagnostic imaging ; Female ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Male ; Malformations and congenital and or hereditary diseases involving bones. Joint deformations ; Medical sciences ; Osteopetrosis - diagnostic imaging ; Osteopetrosis - therapy ; Pelvis - diagnostic imaging ; Radiography ; Ribs - diagnostic imaging ; Time Factors</subject><ispartof>Pediatric radiology, 2001-12, Vol.31 (12), p.869-875</ispartof><rights>2002 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-f758d77531d5871078da6a2c240e7d3d054f4ab1d25e7698af20d0a6ee3548323</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14152363$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11727023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHEOW, Heok K</creatorcontrib><creatorcontrib>STEWARD, Colin G</creatorcontrib><creatorcontrib>GRIER, David J</creatorcontrib><title>Imaging of malignant infantile osteopetrosis before and after bone marrow transplantation</title><title>Pediatric radiology</title><addtitle>Pediatr Radiol</addtitle><description>Malignant infantile osteopetrosis (MIOP) is a sclerosing bone disease caused by absence or defective function of osteoclasts. Since these are of haemopoietic origin, the disease can be cured by allogeneic stem-cell transplantation, but there are no detailed studies of radiological follow-up of these procedures.
To investigate the radiological findings at presentation and follow-up in children undergoing bone marrow transplantation (BMT) for MIOP.
Examination of the records and imaging studies of nine paediatric patients undergoing BMT for MIOP during 1988-2000.
Presentation findings included characteristic features such as fractures, subperiosteal new bone formation and rachitic appearances. Five children engrafted successfully, allowing assessment of the nature and speed of resolution of radiological features after transplantation.
Radiological improvement was apparent within 2 months of successful engraftment with almost complete resolution of abnormalities after 1 year. Studies in two children who are, respectively, 58 and 83 months post-transplant show complete resolution of all bone changes.</description><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation</subject><subject>Diseases of the osteoarticular system</subject><subject>Extremities - diagnostic imaging</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Malformations and congenital and or hereditary diseases involving bones. Joint deformations</subject><subject>Medical sciences</subject><subject>Osteopetrosis - diagnostic imaging</subject><subject>Osteopetrosis - therapy</subject><subject>Pelvis - diagnostic imaging</subject><subject>Radiography</subject><subject>Ribs - diagnostic imaging</subject><subject>Time Factors</subject><issn>0301-0449</issn><issn>1432-1998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNpd0E1LJDEQBuAgis6qR68SBPfWa-Wrkz6K-DEg7EUPnppMpzJEepIx6UH890YdED1VHZ4qql5CThj8YwD6ogBwqaH2AGaHzJgUvGFdZ3bJDASwBqTsDsifUp6rEIqJfXLAmOYauJiRp_nKLkNc0uTpyo5hGW2caIi-ljAiTWXCtMYppxIKXaBPGamNjlo_YaaLFLHO5Zxe6ZRtLOuxDtoppHhE9rwdCx5v6yF5vLl-uLpr7v_fzq8u75tByHZqvFbGaa0Ec8poBto421o-cAmonXCgpJd2wRxXqNvOWM_BgW0RhZJGcHFI_n7tXef0ssEy9atQBhzrIZg2pddcMNF2qsKzX_A5bXKst_Wc81YZ84maLzTUj0tG369zqA--9Qz6j8D7H4FXf7pdulms0H3rbcIVnG-BLYMdfQ1pCOXbSaa4aIV4B8W4h2U</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>CHEOW, Heok K</creator><creator>STEWARD, Colin G</creator><creator>GRIER, David J</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20011201</creationdate><title>Imaging of malignant infantile osteopetrosis before and after bone marrow transplantation</title><author>CHEOW, Heok K ; STEWARD, Colin G ; GRIER, David J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-f758d77531d5871078da6a2c240e7d3d054f4ab1d25e7698af20d0a6ee3548323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Bone Marrow Transplantation</topic><topic>Diseases of the osteoarticular system</topic><topic>Extremities - diagnostic imaging</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Malformations and congenital and or hereditary diseases involving bones. Joint deformations</topic><topic>Medical sciences</topic><topic>Osteopetrosis - diagnostic imaging</topic><topic>Osteopetrosis - therapy</topic><topic>Pelvis - diagnostic imaging</topic><topic>Radiography</topic><topic>Ribs - diagnostic imaging</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHEOW, Heok K</creatorcontrib><creatorcontrib>STEWARD, Colin G</creatorcontrib><creatorcontrib>GRIER, David J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Consumer Health Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Family Health Database (Proquest)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHEOW, Heok K</au><au>STEWARD, Colin G</au><au>GRIER, David J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Imaging of malignant infantile osteopetrosis before and after bone marrow transplantation</atitle><jtitle>Pediatric radiology</jtitle><addtitle>Pediatr Radiol</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>31</volume><issue>12</issue><spage>869</spage><epage>875</epage><pages>869-875</pages><issn>0301-0449</issn><eissn>1432-1998</eissn><coden>PDRYA5</coden><abstract>Malignant infantile osteopetrosis (MIOP) is a sclerosing bone disease caused by absence or defective function of osteoclasts. Since these are of haemopoietic origin, the disease can be cured by allogeneic stem-cell transplantation, but there are no detailed studies of radiological follow-up of these procedures.
To investigate the radiological findings at presentation and follow-up in children undergoing bone marrow transplantation (BMT) for MIOP.
Examination of the records and imaging studies of nine paediatric patients undergoing BMT for MIOP during 1988-2000.
Presentation findings included characteristic features such as fractures, subperiosteal new bone formation and rachitic appearances. Five children engrafted successfully, allowing assessment of the nature and speed of resolution of radiological features after transplantation.
Radiological improvement was apparent within 2 months of successful engraftment with almost complete resolution of abnormalities after 1 year. Studies in two children who are, respectively, 58 and 83 months post-transplant show complete resolution of all bone changes.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>11727023</pmid><doi>10.1007/s002470100008</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-0449 |
| ispartof | Pediatric radiology, 2001-12, Vol.31 (12), p.869-875 |
| issn | 0301-0449 1432-1998 |
| language | eng |
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| source | Springer Nature |
| subjects | Biological and medical sciences Bone Marrow Transplantation Diseases of the osteoarticular system Extremities - diagnostic imaging Female Follow-Up Studies Humans Infant Infant, Newborn Male Malformations and congenital and or hereditary diseases involving bones. Joint deformations Medical sciences Osteopetrosis - diagnostic imaging Osteopetrosis - therapy Pelvis - diagnostic imaging Radiography Ribs - diagnostic imaging Time Factors |
| title | Imaging of malignant infantile osteopetrosis before and after bone marrow transplantation |
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