Spontaneous remission in adult patients with de novo myelodysplastic syndrome: a possible event

Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, via Benevento 6, 00161 Rome, Italy. BACKGROUND AND OBJECTIVES: Spontaneous remission (SR) in de novo myelodysplastic syndromes (MDS) is a rare event, which has been so far described only in children with monosomy 7. The p...

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Bibliographic Details
Published in:Haematologica (Roma) 2001-12, Vol.86 (12), p.1277-1280
Main Authors: Petti, MC, Latagliata, R, Breccia, M, Alimena, G, Spadea, A, D'Andrea, M, Mancini, M, Aloe Spiriti, MA, Mandelli, F
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Female
Hematologic and hematopoietic diseases
Humans
Incidence
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Myelodysplastic Syndromes - blood
Myelodysplastic Syndromes - diagnosis
Myelodysplastic Syndromes - genetics
Remission, Spontaneous
Retrospective Studies
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Summary:Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, via Benevento 6, 00161 Rome, Italy. BACKGROUND AND OBJECTIVES: Spontaneous remission (SR) in de novo myelodysplastic syndromes (MDS) is a rare event, which has been so far described only in children with monosomy 7. The phenomenon is extremely heterogeneous, perhaps depending on different pathogeneses of the disease. DESIGN AND METHODS: We retrospectively evaluated the outcome of 564 consecutive adult patients with primary MDS diagnosed at our Institution in a 12-year period. SR was defined as an unexpected improvement lasting more than 1 year without concomitant treatments other than vitamins or low-dose steroids (in patients with platelets
ISSN:0390-6078
1592-8721