Type 2 diabetes and the metabolic syndrome in Japanese Americans

Japanese Americans have experienced a higher prevalence of type 2 diabetes than in Japan. Research conducted in Seattle suggests that lifestyle factors associated with ‘westernization’ play a role in bringing out this susceptibility to diabetes. These lifestyle factors include consumption of a diet...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2000-10, Vol.50, p.S73-S76
Main Authors: Fujimoto, Wilfred Y, Bergstrom, Richard W, Boyko, Edward J, Chen, Kwang-Wen, Kahn, Steven E, Leonetti, Donna L, McNeely, Marguerite J, Newell, Laura L, Shofer, Jane B, Wahl, Patricia W
Format: Article
Language:English
Subjects:
Adipose Tissue - anatomy & histology
Asian Americans - statistics & numerical data
Associated diseases and complications
Biological and medical sciences
Central adiposity
Coronary Disease - epidemiology
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - etiology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Humans
Insulin Resistance
Japan - ethnology
Life Style
Male
Medical sciences
Prevalence
Risk Factors
Type 2 diabetes
United States - epidemiology
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Summary:Japanese Americans have experienced a higher prevalence of type 2 diabetes than in Japan. Research conducted in Seattle suggests that lifestyle factors associated with ‘westernization’ play a role in bringing out this susceptibility to diabetes. These lifestyle factors include consumption of a diet higher in saturated fat and reduced physical activity. A consequence of this is the development of central (visceral) adiposity, insulin resistance, and other features associated with this insulin resistance metabolic syndrome, such as dyslipidemia (high triglycerides, low HDL-cholesterol, and small and dense LDL particles), hypertension, and coronary heart disease. We have postulated that the superimposition of insulin resistance upon a genetic background of reduced β-cell reserve results in hyperglycemia and diabetes among Japanese Americans. This article reviews evidence that support this view.
ISSN:0168-8227
1872-8227
DOI:10.1016/S0168-8227(00)00182-0