Papillary squamous cell carcinoma of the oral mucosa : immunohistochemical comparison with other carcinomas of oral mucosal origin

Papillary squamous cell carcinoma (PSCC) is a poorly described variant of squamous cell carcinoma, and may be confused with verrucous carcinoma of the head and neck. To add to existing knowledge of this rare tumor, we describe two cases of PSCC arising in the oral mucosa. The lesions were composed o...

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Bibliographic Details
Published in:Journal of Oral Science 2001, Vol.43(3), pp.165-169
Main Authors: Takeda, Yasunori, Satoh, Masanobu, Nakamura, Shin-ichi, Yamamoto, Hirotsugu
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Squamous Cell - chemistry
Carcinoma, Squamous Cell - pathology
Carcinoma, Verrucous - chemistry
Carcinoma, Verrucous - pathology
Cell Division
Dentistry
Diagnosis, Differential
Humans
Immunohistochemistry
Ki-67
Ki-67 Antigen - analysis
Male
Mouth Mucosa - pathology
Mouth Neoplasms - chemistry
Mouth Neoplasms - pathology
Neoplasm Invasiveness
oral carcinoma
papillary squamous cell carcinoma
proliferative activity
Statistics, Nonparametric
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Summary:Papillary squamous cell carcinoma (PSCC) is a poorly described variant of squamous cell carcinoma, and may be confused with verrucous carcinoma of the head and neck. To add to existing knowledge of this rare tumor, we describe two cases of PSCC arising in the oral mucosa. The lesions were composed of exophytic proliferation of atypical to overtly malignant cells similar to those of conventional squamous cell carcinoma, and invasion into the superficial region of the underlying fibrous tissue was seen in the form of islands and cords of malignant cells. Immunohistochemical assessment of cellular proliferative activity showed a significantly high mean percentage of Ki-67 expression in comparison with verrucous carcinoma, but there was no significant difference of Ki-67 expression among PSCC, conventional squamous cell carcinoma and microinvasive squamous cell carcinoma. These results suggest that the biological behavior of PSCC is analogous to that of SCC. (J. Oral Sci. 43, 165-169, 2001)
ISSN:1343-4934
1880-4926
DOI:10.2334/josnusd.43.165