Ovine Adenovirus Serotype 7-associated Mortality in Lambs in the United States

Adenoviral infections were diagnosed in three neonatal lambs that died spontaneously, and no other etiologic agents were identified. Clinical signs were anorexia, weakness, abdominal distention, and sudden death. Microscopic lesions consisted of multifocal necrotizing hepatitis, multifocal subacute...

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Bibliographic Details
Published in:Veterinary pathology 2001-11, Vol.38 (6), p.644-648
Main Authors: Debey, B. M., Lehmkuhl, H. D., Chard-Bergstrom, C., Hobbs, L. A.
Format: Article
Language:English
Subjects:
Adenoviridae - classification
Adenoviridae - genetics
Adenoviridae - isolation & purification
Adenoviridae Infections - pathology
Adenoviridae Infections - veterinary
Adenoviridae Infections - virology
Amino Acid Sequence
Animals
Animals, Newborn
Antigens, Viral - analysis
DNA, Viral - chemistry
DNA, Viral - genetics
DNA, Viral - isolation & purification
Immunohistochemistry - veterinary
Kansas
Kidney - pathology
Kidney - virology
Liver - pathology
Liver - virology
Molecular Sequence Data
Neutralization Tests - veterinary
Sequence Analysis, DNA
Sheep
Sheep Diseases - pathology
Sheep Diseases - virology
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Summary:Adenoviral infections were diagnosed in three neonatal lambs that died spontaneously, and no other etiologic agents were identified. Clinical signs were anorexia, weakness, abdominal distention, and sudden death. Microscopic lesions consisted of multifocal necrotizing hepatitis, multifocal subacute interstitial nephritis, and loss of enterocytes from intestinal villi. Adenovirus inclusions were identified by light microscopy in the kidneys only. Adenoviral antigen, however, was identified in the liver, kidney, and intestine of the lambs by immunohistochemical techniques. An ovine adenovirus serotype 7, not previously isolated from sheep in the United States, was characterized from these lambs.
ISSN:0300-9858
1544-2217
DOI:10.1354/vp.38-6-644