The effect of adsorbed fibrinogen, fibronectin, von Willebrand factor and vitronectin on the procoagulant state of adherent platelets

Procoagulant (activated) platelets provide a site for assembly of the prothrombinase complex which can rapidly convert prothrombin into thrombin (a potent inducer of clot formation). Previously, we reported that adhesion of platelets to surfaces preadsorbed with blood plasma caused them to become pr...

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Bibliographic Details
Published in:Biomaterials 2000-11, Vol.21 (22), p.2243-2252
Main Authors: Grunkemeier, J.M, Tsai, W.B, McFarland, C.D, Horbett, T.A
Format: Article
Language:English
Subjects:
Adsorption
Blood Platelets - drug effects
Blood Platelets - physiology
Fibrinogen
Fibrinogen - physiology
Fibronectin
Fibronectins - pharmacology
Fibronectins - physiology
Humans
In Vitro Techniques
Platelet Activation - physiology
Platelet adhesion
Platelet Adhesiveness - physiology
Procoagulant activity
Thrombin
Thrombin - physiology
Vitronectin
Vitronectin - pharmacology
Vitronectin - physiology
von Willebrand Factor - physiology
vWF
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Summary:Procoagulant (activated) platelets provide a site for assembly of the prothrombinase complex which can rapidly convert prothrombin into thrombin (a potent inducer of clot formation). Previously, we reported that adhesion of platelets to surfaces preadsorbed with blood plasma caused them to become procoagulant. In the present study we investigated the effect of adsorbed adhesion proteins (fibrinogen (Fg), fibronectin (Fn), von Willebrand factor (vWF) and vitronectin (Vn)) on the procoagulant activity of adherent platelets. Adsorbed Fn, vWF and Fg promoted platelet adhesion in the following order: Fn
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(00)00150-2