Sequential expression of annexin A5 in the vasculature and skeletal elements during mouse development

Annexin A5 (annexin V, anchorin CII) represents the prototype member of the large annexin family, characterized by its ability to interact with phospholipids in a calcium-dependent manner and to form calcium-specific ion channels. Despite intense biochemical analysis, the in vivo expression and func...

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Bibliographic Details
Published in:Mechanisms of development 2001-12, Vol.109 (2), p.389-393
Main Authors: Brachvogel, B, Welzel, H, Moch, H, von der Mark, K, Hofmann, C, Pöschl, E
Format: Article
Language:English
Subjects:
Animals
Annexin A5 - biosynthesis
Blood Vessels - embryology
Bone and Bones - embryology
Cell Lineage
Genes, Reporter
Immunohistochemistry
In Situ Hybridization
Lac Operon
Mice
Models, Genetic
Protein Binding
RNA, Messenger - metabolism
Time Factors
Tissue Distribution
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Summary:Annexin A5 (annexin V, anchorin CII) represents the prototype member of the large annexin family, characterized by its ability to interact with phospholipids in a calcium-dependent manner and to form calcium-specific ion channels. Despite intense biochemical analysis, the in vivo expression and function of this annexin during mouse development, still remains unclear. Immunohistochemistry, in situ hybridization and reporter gene expression were used to define expression of annexin A5 during early mouse development. First, annexin A5 expression is associated with the developing vascular system. Later, expression is detected within the notochord and found in parallel to the differentiation of cartilage and bone. Therefore, expression of the Anxa5 gene may represent a novel marker characterizing cell lineages involved in the development of the vascular as well as the skeletal system.
ISSN:0925-4773
DOI:10.1016/s0925-4773(01)00532-9