Neuroimaging studies of the hippocampus in schizophrenia

Three neuroimaging techniques, morphometric neuroimaging, magnetic resonance spectroscopy, and functional neuroimaging, have provided evidence for abnormal hippocampal structure and function in schizophrenia. Hippocampal volume reduction is now one of the most consistent structural abnormalities fou...

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Bibliographic Details
Published in:Hippocampus 2001-10, Vol.11 (5), p.520-528
Main Author: Heckers, Stephan
Format: Article
Language:English
Subjects:
blood flow
Cerebrovascular Circulation
hippocampal function
hippocampal volume
Hippocampus - pathology
Hippocampus - physiopathology
Humans
Memory
Schizophrenia - pathology
Schizophrenia - physiopathology
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Summary:Three neuroimaging techniques, morphometric neuroimaging, magnetic resonance spectroscopy, and functional neuroimaging, have provided evidence for abnormal hippocampal structure and function in schizophrenia. Hippocampal volume reduction is now one of the most consistent structural abnormalities found in schizophrenia: it is present at the onset of the illness and, to a lesser degree, in first‐degree relatives of schizophrenic probands. Decreased levels of N‐acetyl‐aspartate point towards a cellular basis of such volume changes. Functional neuroimaging studies have demonstrated abnormal levels of hippocampal activity at rest, during the experience of auditory hallucinations, and during the performance of memory retrieval tasks. These results of neuroimaging studies complement evidence from post‐mortem and behavioral studies, which have found regionally specific abnormalities of the hippocampus and of memory function in schizophrenia. Hippocampus 2001;11:520–528. © 2001 Wiley‐Liss, Inc.
ISSN:1050-9631
1098-1063
DOI:10.1002/hipo.1068