Clinical rubella reinfection during pregnancy in a previously vaccinated woman

We report a documented case of clinically apparent rubella reinfection during pregnancy with rubelliform rash and fever followed by lymphodenopathy at the 18th week of gestation, in a previously vaccinated woman with haemagglutination inhibition (HI) antibody titre of 1:32. The serological tests res...

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Bibliographic Details
Published in:The Journal of infection 2000-09, Vol.41 (2), p.187-189
Main Authors: ABOUDY, Y, BARNEA, B, YOSEF, L, FRANK, T, MENDELSON, E
Format: Article
Language:English
Subjects:
Adult
Antibodies, Viral - blood
Biological and medical sciences
Diseases of mother, fetus and pregnancy
Female
Fetal Blood - immunology
Gynecology. Andrology. Obstetrics
Hemagglutination Inhibition Tests
Humans
Immunoglobulin G - blood
Immunoglobulin M - blood
Medical sciences
Pregnancy
Pregnancy Complications, Infectious - immunology
Pregnancy Trimester, Second
Pregnancy. Fetus. Placenta
Recurrence
Rubella - immunology
Rubella Vaccine
Rubella virus - immunology
Serologic Tests
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Summary:We report a documented case of clinically apparent rubella reinfection during pregnancy with rubelliform rash and fever followed by lymphodenopathy at the 18th week of gestation, in a previously vaccinated woman with haemagglutination inhibition (HI) antibody titre of 1:32. The serological tests results (including neutralizing antibodies) demonstrated a significant rise in her rubella specific IgG level with strongly positive IgM reactivity. In addition, rubella-specific IgG antibody avidity testing displayed high avidity index (53-88%) typical of rubella reinfection. Umbilical cord blood, drawn by sonographic-guided cordocentesis at 24 weeks' gestation, was found to be negative for rubella-specific IgM antibody. The pregnancy was continued to term, and a healthy infant was born.
ISSN:0163-4453
1532-2742
DOI:10.1053/jinf.2000.0716