Factors predicting response to splenectomy in adult patients with idiopathic thrombocytopenic purpura

Servizio di Ematologia Diagnostica, Ospedale Maggiore, IRCCS, via Francesco Sforza 35, 20122 Milan, Italy. caabsa@tin.it BACKGROUND AND OBJECTIVES. Splenectomy is the treatment of choice in the majority of patients affected by idiopathic thrombocytopenic purpura refractory to corticosteroid therapy,...

Full description

Saved in:
Bibliographic Details
Published in:Haematologica (Roma) 2000-10, Vol.85 (10), p.1040-1044
Main Authors: Radaelli, F, Faccini, P, Goldaniga, M, Guggiari, E, Pozzoli, E, Maiolo, AT, Ciani, A, Pogliani, EM
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Biological and medical sciences
Child
Female
Hematologic and hematopoietic diseases
Humans
Male
Medical sciences
Middle Aged
Multivariate Analysis
Platelet Count
Platelet diseases and coagulopathies
Predictive Value of Tests
Prognosis
Purpura, Thrombocytopenic, Idiopathic - blood
Purpura, Thrombocytopenic, Idiopathic - physiopathology
Purpura, Thrombocytopenic, Idiopathic - surgery
Sex Factors
Splenectomy
Treatment Outcome
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Servizio di Ematologia Diagnostica, Ospedale Maggiore, IRCCS, via Francesco Sforza 35, 20122 Milan, Italy. caabsa@tin.it BACKGROUND AND OBJECTIVES. Splenectomy is the treatment of choice in the majority of patients affected by idiopathic thrombocytopenic purpura refractory to corticosteroid therapy, but it is not free from early and late complications. As the available literature does not seem to contain any precise indications concerning possible factors predicting the response to splenectomy, the aim of this retrospective study of 65 splenectomized patients was to attempt to identify potentially predictive clinical or laboratory parameters. DESIGN AND METHODS. For the purposes of statistical analysis, the patients were divided into two groups: the first included those with a complete (platelets > 100x10(9)/L) or partial response (platelets 50-100 x10(9)/L) to splenectomy; the second, the non-responders (platelets
ISSN:0390-6078
1592-8721