Computer-Assisted Image Analysis of the Rat Postosteonecrotic Remodeled Femoral Head

Osteonecrosis of rat femoral heads was induced by stripping the periosteum of the neck and cutting the ligamentum teres. The epiphyseal marrow and bone were necrotic on the 5th postoperative day. Specimens obtained 18 and 36 days postoperatively showed fibrous and hematopoietic-fatty tissue in the i...

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Bibliographic Details
Published in:Experimental and molecular pathology 2001-12, Vol.71 (3), p.256-264
Main Authors: Sabo, Edmond, Peskin, Bezalel, Misselevich, Ines, Zinman, Chaim, Levin, Daniel, Norman, Doron, Reis, Daniel N., Boss, Jochanan H.
Format: Article
Language:English
Subjects:
animal model of human disease
Animals
architectural remodeling of the femoral head
Biological and medical sciences
Bone Remodeling
computer-assisted image analysis
Disease Models, Animal
Diseases of the osteoarticular system
Femur Head - pathology
Femur Head - surgery
Follow-Up Studies
Image Processing, Computer-Assisted
Male
Medical sciences
Miscellaneous. Osteoarticular involvement in other diseases
Osteonecrosis - pathology
Osteonecrosis - surgery
osteonecrosis of the femoral head
Perthes disease
Rats
Rats, Sprague-Dawley
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Summary:Osteonecrosis of rat femoral heads was induced by stripping the periosteum of the neck and cutting the ligamentum teres. The epiphyseal marrow and bone were necrotic on the 5th postoperative day. Specimens obtained 18 and 36 days postoperatively showed fibrous and hematopoietic-fatty tissue in the intertrabecular spaces, osteoclastic bone resorption, osteogenesis, and degeneration of the joint cartilage. Morphometrically, the means of the height-to-length ratios of the control, 6-day, 18-day, and 36-day femoral heads were 0.26, 0.28, 0.48, and 0.29, respectively. The shape factor of the femoral heads of the control rats was higher than 0.81 in 80% of the cases, while those of rats killed on the 6th, 18th, and 36th postoperative day were higher than 0.81 in 65, 60, and 50% of cases, respectively. Statistically, the means of the height-to-length ratios and the values of the shape factors of the femoral heads of the rats killed 18 days postoperatively differed significantly from those of the other three groups of rats. The quantitatively gauged data of the remodeled epiphyses negate the authors' subjective impression concerning early flattening of the femoral heads after surgically produced osteonecrosis.
ISSN:0014-4800
1096-0945
DOI:10.1006/exmp.2001.2394