Eosinophilic Cystitis in a 4-Year-Old Boy: Successful Long-Term Treatment With Cyclosporin A

A 4-year-old Jewish boy presented with dysuria, urinary dribbling, increased urinary frequency, and new onset of diurnal enuresis. An infiltrating solid mass involving the entire bladder wall was found. Biopsy revealed "tumor-forming" eosinophilic cystitis, a rare bladder lesion of unclear...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2001-12, Vol.108 (6), p.e113-e113
Main Authors: Pomeranz, Avishalom, Eliakim, Alon, Uziel, Yosef, Gottesman, Giora, Rathaus, Valeria, Zehavi, Tanya, Wolach, Baruch
Format: Article
Language:English
Subjects:
Child, Preschool
Cyclosporine - therapeutic use
Cystitis - diagnosis
Cystitis - drug therapy
Cystitis - immunology
Eosinophilia - diagnosis
Eosinophilia - drug therapy
Humans
Immunosuppressive Agents - therapeutic use
Male
Pediatrics
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Summary:A 4-year-old Jewish boy presented with dysuria, urinary dribbling, increased urinary frequency, and new onset of diurnal enuresis. An infiltrating solid mass involving the entire bladder wall was found. Biopsy revealed "tumor-forming" eosinophilic cystitis, a rare bladder lesion of unclear cause. Antitoxocariasis treatment was unsuccessful. High-dose corticosteroids failed. The child's clinical condition and bladder sonographic findings continued to deteriorate. Treatment with cyclosporin A was given for 8 months, with a complete clinical, radiologic, and histopathologic cure and no side effects. Two years of follow-up showed a complete recovery.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.108.6.e113