Inflammatory Breast Metastases of Ovarian Cancer: A Case Report

Background. Metastasis to the breast from extramammary malignancies is rare. Case. A 35-year-old woman presented with bilaterally inflammatory breast involvement, 2 years after the diagnosis of stage IIIC epithelial ovarian cancer. Neoplastic tissue was immunohistochemically positive using antibodie...

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Bibliographic Details
Published in:Gynecologic oncology 2001-12, Vol.83 (3), p.613-616
Main Authors: Kayikçioğlu, Fulya, Boran, Nurettin, Ayhan, Ayşe, Güler, Nilüfer
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
breast metastasis
Breast Neoplasms - pathology
Breast Neoplasms - secondary
Cystadenocarcinoma, Papillary - pathology
Cystadenocarcinoma, Papillary - secondary
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
ovarian cancer
Ovarian Neoplasms - pathology
Tumors
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Summary:Background. Metastasis to the breast from extramammary malignancies is rare. Case. A 35-year-old woman presented with bilaterally inflammatory breast involvement, 2 years after the diagnosis of stage IIIC epithelial ovarian cancer. Neoplastic tissue was immunohistochemically positive using antibodies against OC125 and negative for gross cystic disease fluid protein-15 (BRST-2) and estrogen receptor in biopsy material in the breast. Combination chemotherapy consisting of paclitaxel, cisplatin, and anthracycline was started. She died 18 months after the breast metastasis. Conclusion. Ovarian carcinoma usually presents with signs and symptoms related to the tumor burden within the abdominal cavity. The finding of isolated, distant metastases such as breast involvement without intraabdominal disease is extremely rare. Determining the origin of the primary tumor is important in directing the actual therapy.
ISSN:0090-8258
1095-6859
DOI:10.1006/gyno.2001.6402