Remnant-like particles cholesterol is higher in diabetic patients with coronary artery disease

Diabetes mellitus (DM) has been well known to be one of the risk factors of coronary artery disease (CAD). Recently, remnant-like particles cholesterol (RLP-C) has been reported to be associated with CAD. However, few studies reported the association of RLP-C level with CAD in subjects with DM. To i...

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Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 2001-12, Vol.50 (12), p.1462-1465
Main Authors: Higashi, Kenji, Ito, Toshimitsu, Nakajima, Kei, Yonemura, Atsushi, Nakamura, Haruo, Ohsuzu, Fumitaka
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Glucose - analysis
Body Mass Index
Cardiology. Vascular system
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Coronary Disease - blood
Coronary Disease - etiology
Coronary heart disease
Diabetes Complications
Diabetes Mellitus - blood
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fasting
Glycated Hemoglobin A - analysis
Heart
Humans
Medical sciences
Middle Aged
Triglycerides - blood
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Summary:Diabetes mellitus (DM) has been well known to be one of the risk factors of coronary artery disease (CAD). Recently, remnant-like particles cholesterol (RLP-C) has been reported to be associated with CAD. However, few studies reported the association of RLP-C level with CAD in subjects with DM. To investigate the effects of presence or absence of DM on the association between RLP-C and CAD, we compared the RLP-C level in 142 male patients with CAD and 123 male subjects without CAD (non-CAD), including 44 and 38 DM patients, respectively. RLP-C was significantly higher in CAD than non-CAD (P [lt ] .05). RLP-C and RLP-C/plasma-triglyceride (TG) ratio in CAD with DM were higher than CAD without DM (P [lt ] .01, P [lt ] .05), and non-CAD with DM (P [lt ] .001, P [lt ] .05). There was positive correlation between RLP-C and plasma-TG in non-CAD without DM (r = .44, P [lt ] .01), non-CAD with DM (r = .56, P [lt ] .001), CAD without DM (r = .81, P [lt ] .0001), and CAD with DM (r = .75, P [lt ] .001). After excluding the hypertriglyceridemic patients ([gt ]200mg/dL), RLP-C/plasma-TG ratio was significantly higher in CAD with DM than CAD without DM (P [lt ] .001) and non-CAD with DM (P [lt ] .05). These results suggest that increased RLP-C to plasma-TG may be associated with CAD in middle-aged diabetic male subjects.
ISSN:0026-0495
1532-8600
DOI:10.1053/meta.2001.27193