Changes of Hemostatic Molecular Markers After Gynecological Surgery

The authors evaluated the hemostatic abnormalities occurring in the postoperative period of eight patients with malignant tumors and compared them with those occurring in the postoperative period of eight patients with benign tumors. Two of the patients with malignant tumor presented pulmonary embol...

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Bibliographic Details
Published in:Clinical and applied thrombosis/hemostasis 2000-10, Vol.6 (4), p.197-201
Main Authors: Noda, Kazuhiko, Wada, Hideo, Yamada, Norikazu, Noda, Naomi, Gabazza, Esteban C., Kumeda, Kouzou, Okugawa, Toshiharu, Yanoh, Kenji, Ito, Masazumi, Nakano, Takeshi, Shiku, Hiroshi, Nobori, Tsutomu, Kato, Hisao, Toyoda, Nagayasu
Format: Article
Language:English
Subjects:
Adult
Aged
Antithrombins - metabolism
Biomarkers - blood
Embolisms
Endometrial Neoplasms - complications
Endometrial Neoplasms - surgery
Female
Genital Neoplasms, Female - complications
Genital Neoplasms, Female - surgery
Gynecologic Surgical Procedures - adverse effects
Hemostatics - blood
Humans
Middle Aged
Neoplasms - complications
Neoplasms - surgery
Partial Thromboplastin Time
Plasma
Platelet Count
Postoperative Complications
Postoperative period
Protein C - metabolism
Proteins
Pulmonary Embolism - blood
Pulmonary Embolism - etiology
Pulmonary embolisms
Risk Factors
Thrombosis - blood
Thrombosis - etiology
Time Factors
Tumors
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Summary:The authors evaluated the hemostatic abnormalities occurring in the postoperative period of eight patients with malignant tumors and compared them with those occurring in the postoperative period of eight patients with benign tumors. Two of the patients with malignant tumor presented pulmonary embolism after operation. Plasma fibrinogen and fibrin degra dation product levels in patients with malignant tumors were already high before operation and further increased signifi cantly after operation. The plasma levels of D-dimer, thrombi n-antithrombin complex, and free-tissue factor pathway inhibi tor were increased in both groups after operation, but they were higher in patients with malignant tumors than in patients with benign tumors. The plasma levels of protein C and antithrom bin were significantly decreased in both groups after operation, but they were significantly lower in patients with malignant tumors than in those with benign tumors. The decreased activ ity of protein C or antithrombin may be not only a risk factor of thrombotic disease, such as pulmonary embolism, but also the cause of thrombosis. In patients with malignant tumors, the operation time was significantly longer than that in patients with benign tumors. This long operative period might cause vascular endothelial cell injury which is reflected by the plasma levels of free-tissue factor pathway inhibitor, antithrombin, and protein C.
ISSN:1076-0296
1938-2723
DOI:10.1177/107602960000600403