Costimulation of T cells

Costimulation is critical to T cell activation. On the antigen-presenting cell the key players are found in the extended family of B7 genes comprising cd80, cd86, B7h/B7RP-1 and B7-H1. cd80 and cd86 encode proteins that bind to CD28 and CTLA4 on T cells. Blocking this pathway with the potent CTLA4-I...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2000-10, Vol.162 (4), p.S164-S168
Main Authors: BUGEON, Laurence, DALLMAN, Margaret J
Format: Article
Language:English
Subjects:
Antigen-Presenting Cells - immunology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genes, MHC Class II - genetics
Humans
Immunobiology
Lymphocyte Activation - genetics
Lymphocyte Activation - immunology
Lymphocyte Cooperation - genetics
Lymphocyte Cooperation - immunology
Modulation of the immune response (stimulation, suppression)
T-Lymphocyte Subsets - immunology
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Summary:Costimulation is critical to T cell activation. On the antigen-presenting cell the key players are found in the extended family of B7 genes comprising cd80, cd86, B7h/B7RP-1 and B7-H1. cd80 and cd86 encode proteins that bind to CD28 and CTLA4 on T cells. Blocking this pathway with the potent CTLA4-Ig fusion protein shows encouraging potential as a therapeutic agent. While cd80 and cd86 pathways act mainly on naive T cells, B7h/B7RP-1 and B7-H1 seem to exert their effects on antigen-experienced lymphocytes.
ISSN:1073-449X
1535-4970
DOI:10.1164/ajrccm.162.supplement_3.15tac5