Orbitofrontal involvement in the processing of unpleasant auditory information

Although little is known about the contribution of the orbitofrontal cortex to the processing of new information in man, lesion studies in monkeys have suggested that it plays a critical role. The present study investigated changes in cerebral blood flow with positron emission tomography in normal h...

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Bibliographic Details
Published in:The European journal of neuroscience 2000-10, Vol.12 (10), p.3709-3712
Main Authors: Frey, S., Kostopoulos, P., Petrides, M.
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Adult
area 13
auditory information
Auditory Pathways - anatomy & histology
Auditory Pathways - physiology
Auditory Perception - physiology
Brain Mapping
Cerebrovascular Circulation - physiology
Emotions - physiology
Experiments
Female
human
Humans
Magnetic resonance imaging
orbitofrontal
PET
Prefrontal Cortex - anatomy & histology
Prefrontal Cortex - diagnostic imaging
Prefrontal Cortex - physiology
Sound
Tomography
Tomography, Emission-Computed
Traffic accidents & safety
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Summary:Although little is known about the contribution of the orbitofrontal cortex to the processing of new information in man, lesion studies in monkeys have suggested that it plays a critical role. The present study investigated changes in cerebral blood flow with positron emission tomography in normal human subjects during exposure to unpleasant auditory stimuli. The results indicated that the caudal orbitofrontal cortex, area 13, which is powerfully linked to the medial temporal limbic region and is involved in the regulation of autonomic responses, is a key part of the frontal cortex responding in the face of unpleasant incoming information.
ISSN:0953-816X
1460-9568
DOI:10.1046/j.1460-9568.2000.00227.x