Deletion 5p11 accompanied by multiple numerical changes in testicular lymphoma

We describe a case of testicular B cell lymphoma with deletion of chromosome 5, del(5)(p11), as a sole structural abnormality. Histopathological diagnosis of the tumor was a high-grade lymphoma of the diffuse type containing cells positive for B cell specific antigen (CD20) and negative for the leuk...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2001-11, Vol.131 (1), p.79-81
Main Authors: Espinoza, Luis A., Neto, José Barbieri, Popescu, Nicholas C., Casartelli, Cacilda
Format: Article
Language:English
Subjects:
Aged
Antigens, CD20 - analysis
Biological and medical sciences
Chromosome Deletion
Chromosomes, Human, Pair 5 - genetics
Disease Progression
Genes, Tumor Suppressor
Gynecology. Andrology. Obstetrics
Humans
Karyotyping
Leukocyte Common Antigens - analysis
Lymphoma - genetics
Lymphoma - metabolism
Lymphoma - pathology
Male
Male genital diseases
Medical sciences
Neoplasm Invasiveness - genetics
Neoplasm Invasiveness - pathology
Prognosis
Testicular Neoplasms - genetics
Testicular Neoplasms - metabolism
Testicular Neoplasms - pathology
Tumors
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Summary:We describe a case of testicular B cell lymphoma with deletion of chromosome 5, del(5)(p11), as a sole structural abnormality. Histopathological diagnosis of the tumor was a high-grade lymphoma of the diffuse type containing cells positive for B cell specific antigen (CD20) and negative for the leukocyte common antigen (CD45). Deletion 5p may define the region of a tumor suppressor gene that could be associated with tumor progression and invasiveness and may serve as an indicator of poor prognosis in testicular lymphomas.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(01)00495-2