Allergy-associated polymorphisms of the Fc epsilon RI beta subunit do not impact its two amplification functions

Two variants of the beta-chain of the high affinity IgE receptor Fc epsilon RI, I181L-V183L and E237G, have been found associated with allergy. We have previously shown that the beta-chain plays at least two distinct amplifier functions. It amplifies Fc epsilon RI surface expression and signaling, r...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2000-10, Vol.165 (7), p.3917-3922
Main Authors: Donnadieu, E, Cookson, W O, Jouvin, M H, Kinet, J P
Format: Article
Language:English
Subjects:
AFc receptors
Basophils - immunology
Basophils - metabolism
Cell Line
Cell Membrane - genetics
Cell Membrane - immunology
Cell Membrane - metabolism
Gene Amplification - immunology
Genetic Variation - immunology
Glutamic Acid - genetics
Glycine - genetics
Humans
Hypersensitivity, Immediate - genetics
Hypersensitivity, Immediate - immunology
Intracellular Fluid - immunology
Intracellular Fluid - metabolism
Isoleucine - genetics
Leucine - genetics
Polymorphism, Genetic - immunology
Protein Processing, Post-Translational - immunology
Receptors, IgE - biosynthesis
Receptors, IgE - genetics
Receptors, IgE - metabolism
Transfection
U937 Cells
Valine - genetics
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Summary:Two variants of the beta-chain of the high affinity IgE receptor Fc epsilon RI, I181L-V183L and E237G, have been found associated with allergy. We have previously shown that the beta-chain plays at least two distinct amplifier functions. It amplifies Fc epsilon RI surface expression and signaling, resulting in an estimated 12- to 30-fold amplification of downstream events. To test the hypothesis that the I181L-V183L and E237G beta variants may be functionally relevant and could directly contribute to an allergic phenotype, we have evaluated the functional impact of the beta variants on the two amplifier functions of beta. We found that these variants have no direct effect on the beta amplifier functions. However, the possibility remains that these variants are in linkage disequilibrium with other more relevant polymorphisms or are affecting unknown beta-chain functions.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.165.7.3917