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Allergy-associated polymorphisms of the Fc epsilon RI beta subunit do not impact its two amplification functions
Two variants of the beta-chain of the high affinity IgE receptor Fc epsilon RI, I181L-V183L and E237G, have been found associated with allergy. We have previously shown that the beta-chain plays at least two distinct amplifier functions. It amplifies Fc epsilon RI surface expression and signaling, r...
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| Published in: | The Journal of immunology (1950) 2000-10, Vol.165 (7), p.3917-3922 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c2927-8dd68782188ddefa24f4fa4eb6ce55d261e2c4fd77b3fdfb801beddec967fd633 |
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| cites | cdi_FETCH-LOGICAL-c2927-8dd68782188ddefa24f4fa4eb6ce55d261e2c4fd77b3fdfb801beddec967fd633 |
| container_end_page | 3922 |
| container_issue | 7 |
| container_start_page | 3917 |
| container_title | The Journal of immunology (1950) |
| container_volume | 165 |
| creator | Donnadieu, E Cookson, W O Jouvin, M H Kinet, J P |
| description | Two variants of the beta-chain of the high affinity IgE receptor Fc epsilon RI, I181L-V183L and E237G, have been found associated with allergy. We have previously shown that the beta-chain plays at least two distinct amplifier functions. It amplifies Fc epsilon RI surface expression and signaling, resulting in an estimated 12- to 30-fold amplification of downstream events. To test the hypothesis that the I181L-V183L and E237G beta variants may be functionally relevant and could directly contribute to an allergic phenotype, we have evaluated the functional impact of the beta variants on the two amplifier functions of beta. We found that these variants have no direct effect on the beta amplifier functions. However, the possibility remains that these variants are in linkage disequilibrium with other more relevant polymorphisms or are affecting unknown beta-chain functions. |
| doi_str_mv | 10.4049/jimmunol.165.7.3917 |
| format | article |
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| ispartof | The Journal of immunology (1950), 2000-10, Vol.165 (7), p.3917-3922 |
| issn | 0022-1767 1550-6606 |
| language | eng |
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| source | EZB Electronic Journals Library |
| subjects | AFc receptors Basophils - immunology Basophils - metabolism Cell Line Cell Membrane - genetics Cell Membrane - immunology Cell Membrane - metabolism Gene Amplification - immunology Genetic Variation - immunology Glutamic Acid - genetics Glycine - genetics Humans Hypersensitivity, Immediate - genetics Hypersensitivity, Immediate - immunology Intracellular Fluid - immunology Intracellular Fluid - metabolism Isoleucine - genetics Leucine - genetics Polymorphism, Genetic - immunology Protein Processing, Post-Translational - immunology Receptors, IgE - biosynthesis Receptors, IgE - genetics Receptors, IgE - metabolism Transfection U937 Cells Valine - genetics |
| title | Allergy-associated polymorphisms of the Fc epsilon RI beta subunit do not impact its two amplification functions |
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