Apoplexy of Pituitary Macroadenoma after Combined Test of Anterior Pituitary Function

Pituitary apoplexy has been reported as a very rare complication of combined tests of anterior pituitary function and of TRH or gonadotropin-releasing hormone (GnRH) administration in pituitary tumor. A 34-year-old man with a GH-secreting pituitary macroadenoma and diabetes mellitus received an inje...

Full description

Saved in:
Bibliographic Details
Published in:ENDOCRINE JOURNAL 2000, Vol.47(3), pp.329-333
Main Authors: LEE, DAE HO, CHUNG, MIN YOUNG, CHUNG, DONG JIN, KIM, JUNG MIN, LEE, TAI HEE, NAM, JONG HEE, PARK, CHUNG SOO
Format: Article
Language:English
Subjects:
Acromegaly - complications
Adult
GnRH
Humans
Male
Pituitary apoplexy
Pituitary Apoplexy - complications
Pituitary Apoplexy - etiology
Pituitary Function Tests - adverse effects
Pituitary Gland, Anterior - physiopathology
Pituitary Neoplasms - complications
Pituitary Neoplasms - pathology
TRH
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pituitary apoplexy has been reported as a very rare complication of combined tests of anterior pituitary function and of TRH or gonadotropin-releasing hormone (GnRH) administration in pituitary tumor. A 34-year-old man with a GH-secreting pituitary macroadenoma and diabetes mellitus received an injection of 400μg TRH, 100μg GnRH, and 0.15U/Kg regular insulin. Twenty minutes later, he complained of a severe headache and vomited. Visual acuity and visual field did not change and his headache was persistent during the next 24 hours of conservative management. Magnetic resonance imaging (MRI) of the sella turcica done the day after the event showed definitive elevation of the optic chiasm and slight enlargement of tumor and focal areas of mixed high signal and low signal intensities in the macroadenoma on noncontrast T1-weighted images. Headache subsided markedly within a day of octreotide therapy. Transsphenoidal removal of the pituitary tumor was performed 9 days after the hormone study. Ischemic necrosis and hemorrhage were confirmed in the acidophilic adenoma with positive immunostaining for GH. Postoperative course was uneventful and his serum insulin-like growth factor-1(IGF-1) level and blood glucose levels were normalized. Three months after the surgery the dynamic test was repeated without adverse effects. To our knowledge, this is a very rare case of apoplexy of GH-secreting pituitary adenoma after a combined stimulation test of anterior pituitary function.
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.47.329