Clinical and endoscopic characteristics of non‐Helicobacter pylori, non‐NSAID duodenal ulcers: a long‐term prospective study

Background: The proportion of duodenal ulcers not associated with Helicobacter pylori infection or the use of non‐steroidal anti‐inflammatory drugs (NSAIDs) is increasing. Aim: To identify the clinical and endoscopic characteristics of non‐H. pylori, non‐NSAID duodenal ulcers. Methods: Clinical and...

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Published in:Alimentary pharmacology & therapeutics 2001-12, Vol.15 (12), p.1875-1882
Main Authors: Xia, H. H.‐X., Wong, B. C. Y., Wong, K. W., Wong, S. Y., Wong, W. M., Lai, K. C., Hu, W. H. C., Chan, C. K., Lam, S. K.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Biological and medical sciences
Chronic Disease
Duodenal Ulcer - drug therapy
Duodenal Ulcer - epidemiology
Duodenal Ulcer - microbiology
Endoscopy, Gastrointestinal
Female
Gastroenterology. Liver. Pancreas. Abdomen
Helicobacter Infections - drug therapy
Helicobacter Infections - epidemiology
Helicobacter Infections - microbiology
Helicobacter pylori - isolation & purification
Hong Kong - epidemiology
Humans
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Prevalence
Prospective Studies
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Surveys and Questionnaires
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Summary:Background: The proportion of duodenal ulcers not associated with Helicobacter pylori infection or the use of non‐steroidal anti‐inflammatory drugs (NSAIDs) is increasing. Aim: To identify the clinical and endoscopic characteristics of non‐H. pylori, non‐NSAID duodenal ulcers. Methods: Clinical and endoscopic data and H. pylori status were prospectively collected from consecutive patients who underwent upper endoscopy from 1997 to 1999. Patients with duodenal ulcers were identified, and those with non‐H. pylori, non‐NSAID duodenal ulcers were analysed further. Results: A total of 11 717 upper endoscopies were performed in 8344 patients. Of these, 1153 (14%) had duodenal ulcers. Of 599 patients with active ulcers and known H. pylori status, 104 (17%) had ulcers not associated with H. pylori or the use of NSAIDs, 393 (66%) had ulcers associated with H. pylori alone, 51 (8.5%) had ulcers associated with the use of NSAIDs alone and 51 (8.5%) had ulcers associated with both. Multivariate logistic regression analysis revealed that the presence of concomitant diseases (odds ratio=15.0; 95% confidence interval, 8.64–25.9; P 
ISSN:0269-2813
1365-2036
DOI:10.1046/j.1365-2036.2001.01115.x