Immune therapy in inflammatory bowel disease and models of colitis

Background: A proliferation of animal models has not only improved our understanding of inflammatory bowel disease, it has also formed the basis of new treatment strategies. Methods: A search was conducted using the National Library of Medicine for articles discussing immune therapies for inflammato...

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Bibliographic Details
Published in:British journal of surgery 2001-12, Vol.88 (12), p.1558-1569
Main Authors: Singh, B., Powrie, F., Mortensen, N. J. McC
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Adhesion Molecules - therapeutic use
Clinical Trials as Topic
Disease Models, Animal
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunomodulators
Immunotherapy - methods
Inflammatory Bowel Diseases - therapy
Interleukins - therapeutic use
Medical sciences
Other diseases. Semiology
Pharmacology. Drug treatments
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
T-Lymphocyte Subsets
Tumor Necrosis Factor-alpha - therapeutic use
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Summary:Background: A proliferation of animal models has not only improved our understanding of inflammatory bowel disease, it has also formed the basis of new treatment strategies. Methods: A search was conducted using the National Library of Medicine for articles discussing immune therapies for inflammatory bowel disease. This was supplemented by findings from the authors' own laboratory. Results: An overview of the different animal models is presented. These models are used to highlight the recent human trials of immune therapies. Potential future therapies are also discussed. Conclusion: Immune therapies have altered the management of patients with inflammatory bowel disease. In future they will influence not only the indications for surgery but also its timing and outcome. © 2001 British Journal of Surgery Society Ltd
ISSN:0007-1323
1365-2168
DOI:10.1046/j.0007-1323.2001.01909.x