Prevalence of multiple dideoxynucleoside analogue resistance (MddNR) in a cohort of Italian HIV-1 seropositive patients extensively treated with antiretroviral drugs

As the emergence of highly resistant virus might compromise antiretroviral regimens in HIV-1 infected patients, a constant analysis of genotypic mutations should be performed to establish the magnitude of mutation prevalence and gauge their impact in patients treated extensively with combination the...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2001-12, Vol.18 (6), p.519-523
Main Authors: Re, M.C, Borderi, M, Monari, P, Bon, I, Gorini, R, Gibellini, D, Verucchi, G, Fortunato, L, Chiodo, F, La Placa, M
Format: Article
Language:English
Subjects:
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
antiretroviral therapy
Antiviral agents
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Biological and medical sciences
Cohort Studies
Dideoxynucleosides - pharmacology
Dideoxynucleosides - therapeutic use
Drug Resistance, Multiple, Viral - genetics
Genotype
HIV Infections - drug therapy
HIV Infections - virology
HIV Seropositivity - drug therapy
HIV Seropositivity - virology
HIV-1 - drug effects
HIV-1 - genetics
Human immunodeficiency virus 1
Humans
Italy
Medical sciences
Multiple dideoxynucleoside analogue-resistant HIV-1 variants
Mutation
nucleoside analogs
Pharmacology. Drug treatments
Q151M complex HIV-1 viral load
Viral Load
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Summary:As the emergence of highly resistant virus might compromise antiretroviral regimens in HIV-1 infected patients, a constant analysis of genotypic mutations should be performed to establish the magnitude of mutation prevalence and gauge their impact in patients treated extensively with combination therapy. The frequency of multiple dideoxynucleoside analogue resistance (MddNR) was evaluated in a group of Italian HIV-1 seropositive patients who failed to respond to therapy despite a long-lasting drug treatment. Results showed the presence of one or more mutations (A62V, V75I, F77L, F116Y and Q151M) able to confer resistance to all NRTIs in a relatively high percentage (7.9%) of patients enrolled in the study. Moreover, a significantly lower HIV-1 viral replication in patients with MddNR, suggested the importance of monitoring HIV-1 subjects not only by viral load, but also by drug resistance testing, so that a correct drug regimen may be chosen.
ISSN:0924-8579
1872-7913
DOI:10.1016/S0924-8579(01)00440-X