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Long-term clinical impact of occult hepatitis B virus infection in chronic hepatitis B patients
Background / Aims : Long-term clinical outcomes of occult hepatitis B virus (HBV) infection were studied. Methods : Fifteen chronic hepatitis B patients were monitored for a median of 4.4 years (range 0.9–15.3) after hepatitis B surface antigen (HBsAg) seroclearance. Serum HBV DNA was measured by re...
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| Published in: | Journal of hepatology 2001-12, Vol.35 (6), p.798-804 |
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| Main Authors: | , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c457t-8c172580625ce42c9c616485ca67a090eadd0ae16eebd145669c7b4872771a293 |
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| cites | cdi_FETCH-LOGICAL-c457t-8c172580625ce42c9c616485ca67a090eadd0ae16eebd145669c7b4872771a293 |
| container_end_page | 804 |
| container_issue | 6 |
| container_start_page | 798 |
| container_title | Journal of hepatology |
| container_volume | 35 |
| creator | Komori, Masato Yuki, Nobukazu Nagaoka, Takayuki Yamashiro, Masatoshi Mochizuki, Kiyoshi Kaneko, Akira Yamamoto, Keiji Hikiji, Kazumasa Kato, Michio |
| description | Background
/
Aims
: Long-term clinical outcomes of occult hepatitis B virus (HBV) infection were studied.
Methods
: Fifteen chronic hepatitis B patients were monitored for a median of 4.4 years (range 0.9–15.3) after hepatitis B surface antigen (HBsAg) seroclearance. Serum HBV DNA was measured by real-time detection polymerase chain reaction. Thirteen patients underwent liver biopsies at the end of follow-up and liver histology was evaluated by Ishak score. Liver HBV DNA was also measured for 12 patients.
Results
: At the end of follow-up, HBV viremia was absent in 13 (87%) patients, and antibody titers to hepatitis B core antigen showed an inverse correlation with time from HBsAg seroclearance (
r=−0.554;
P=0.0040). However, all patients retained liver HBV DNA and tested positive for the covalently closed circular HBV DNA replicative intermediate. The hepatic HBV DNA loads had no relation to liver histology. Paired biopsies from 11 patients disclosed that each necroinflammatory score significantly improved after HBsAg seroclearance. Amelioration of liver fibrosis was also evident in eight (73%) patients (
P=0.0391 by signed rank test).
Conclusions: A long-standing but strongly suppressed HBV infection may confer histological amelioration after HBsAg seroclearance. |
| doi_str_mv | 10.1016/S0168-8278(01)00214-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72342292</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168827801002148</els_id><sourcerecordid>72342292</sourcerecordid><originalsourceid>FETCH-LOGICAL-c457t-8c172580625ce42c9c616485ca67a090eadd0ae16eebd145669c7b4872771a293</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhi0EotvCTwD5AoJDYMZxbOdUQVU-pJU4AGfLO3GoURIvtlOJf4-3u6LixGVmDs87M3oYe4bwBgHV26-1mMYIbV4BvgYQKBvzgG1QATSgJD5km7_IGTvP-ScAtNDLx-wMUbcGwWyY3cblR1N8mjlNYQnkJh7mvaPC48gj0ToVfuP3roQSMn_Pb0NaMw_L6KmEuNSJ002KNfkPdpj8UvIT9mh0U_ZPT_2Cff9w_e3qU7P98vHz1bttQ7LTpTGEWnQGlOjIS0E9KVTSdOSUdtCDd8MAzqPyfjeg7JTqSe-k0UJrdKJvL9jL4959ir9Wn4udQyY_TW7xcc1Wi1YK0YsKdkeQUsw5-dHuU5hd-m0R7MGsvTNrD9osoL0za03NPT8dWHezH-5TJ5UVeHECXK4Wx-QWCvmea1sD2KvKXR45X3XcBp9spqqK_BBSdWqHGP7zyh-UUJTx</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72342292</pqid></control><display><type>article</type><title>Long-term clinical impact of occult hepatitis B virus infection in chronic hepatitis B patients</title><source>ScienceDirect Freedom Collection</source><creator>Komori, Masato ; Yuki, Nobukazu ; Nagaoka, Takayuki ; Yamashiro, Masatoshi ; Mochizuki, Kiyoshi ; Kaneko, Akira ; Yamamoto, Keiji ; Hikiji, Kazumasa ; Kato, Michio</creator><creatorcontrib>Komori, Masato ; Yuki, Nobukazu ; Nagaoka, Takayuki ; Yamashiro, Masatoshi ; Mochizuki, Kiyoshi ; Kaneko, Akira ; Yamamoto, Keiji ; Hikiji, Kazumasa ; Kato, Michio</creatorcontrib><description>Background
/
Aims
: Long-term clinical outcomes of occult hepatitis B virus (HBV) infection were studied.
Methods
: Fifteen chronic hepatitis B patients were monitored for a median of 4.4 years (range 0.9–15.3) after hepatitis B surface antigen (HBsAg) seroclearance. Serum HBV DNA was measured by real-time detection polymerase chain reaction. Thirteen patients underwent liver biopsies at the end of follow-up and liver histology was evaluated by Ishak score. Liver HBV DNA was also measured for 12 patients.
Results
: At the end of follow-up, HBV viremia was absent in 13 (87%) patients, and antibody titers to hepatitis B core antigen showed an inverse correlation with time from HBsAg seroclearance (
r=−0.554;
P=0.0040). However, all patients retained liver HBV DNA and tested positive for the covalently closed circular HBV DNA replicative intermediate. The hepatic HBV DNA loads had no relation to liver histology. Paired biopsies from 11 patients disclosed that each necroinflammatory score significantly improved after HBsAg seroclearance. Amelioration of liver fibrosis was also evident in eight (73%) patients (
P=0.0391 by signed rank test).
Conclusions: A long-standing but strongly suppressed HBV infection may confer histological amelioration after HBsAg seroclearance.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/S0168-8278(01)00214-8</identifier><identifier>PMID: 11738108</identifier><identifier>CODEN: JOHEEC</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Adult ; Biological and medical sciences ; Chronic hepatitis B ; DNA, Viral - analysis ; Female ; Hepatitis B Antibodies - analysis ; Hepatitis B Core Antigens - immunology ; Hepatitis B Surface Antigens - analysis ; Hepatitis B virus - genetics ; Hepatitis B virus - isolation & purification ; Hepatitis B virus DNA ; Hepatitis B, Chronic - immunology ; Hepatitis B, Chronic - pathology ; Hepatitis B, Chronic - physiopathology ; Hepatitis B, Chronic - virology ; Human viral diseases ; Humans ; Infectious diseases ; Liver - pathology ; Liver Cirrhosis - pathology ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Occult hepatitis B virus infection ; Polymerase chain reaction ; Viral diseases ; Viral hepatitis ; Viremia - virology</subject><ispartof>Journal of hepatology, 2001-12, Vol.35 (6), p.798-804</ispartof><rights>2001 European Association for the Study of the Liver</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-8c172580625ce42c9c616485ca67a090eadd0ae16eebd145669c7b4872771a293</citedby><cites>FETCH-LOGICAL-c457t-8c172580625ce42c9c616485ca67a090eadd0ae16eebd145669c7b4872771a293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13380196$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11738108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Komori, Masato</creatorcontrib><creatorcontrib>Yuki, Nobukazu</creatorcontrib><creatorcontrib>Nagaoka, Takayuki</creatorcontrib><creatorcontrib>Yamashiro, Masatoshi</creatorcontrib><creatorcontrib>Mochizuki, Kiyoshi</creatorcontrib><creatorcontrib>Kaneko, Akira</creatorcontrib><creatorcontrib>Yamamoto, Keiji</creatorcontrib><creatorcontrib>Hikiji, Kazumasa</creatorcontrib><creatorcontrib>Kato, Michio</creatorcontrib><title>Long-term clinical impact of occult hepatitis B virus infection in chronic hepatitis B patients</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>Background
/
Aims
: Long-term clinical outcomes of occult hepatitis B virus (HBV) infection were studied.
Methods
: Fifteen chronic hepatitis B patients were monitored for a median of 4.4 years (range 0.9–15.3) after hepatitis B surface antigen (HBsAg) seroclearance. Serum HBV DNA was measured by real-time detection polymerase chain reaction. Thirteen patients underwent liver biopsies at the end of follow-up and liver histology was evaluated by Ishak score. Liver HBV DNA was also measured for 12 patients.
Results
: At the end of follow-up, HBV viremia was absent in 13 (87%) patients, and antibody titers to hepatitis B core antigen showed an inverse correlation with time from HBsAg seroclearance (
r=−0.554;
P=0.0040). However, all patients retained liver HBV DNA and tested positive for the covalently closed circular HBV DNA replicative intermediate. The hepatic HBV DNA loads had no relation to liver histology. Paired biopsies from 11 patients disclosed that each necroinflammatory score significantly improved after HBsAg seroclearance. Amelioration of liver fibrosis was also evident in eight (73%) patients (
P=0.0391 by signed rank test).
Conclusions: A long-standing but strongly suppressed HBV infection may confer histological amelioration after HBsAg seroclearance.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chronic hepatitis B</subject><subject>DNA, Viral - analysis</subject><subject>Female</subject><subject>Hepatitis B Antibodies - analysis</subject><subject>Hepatitis B Core Antigens - immunology</subject><subject>Hepatitis B Surface Antigens - analysis</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Hepatitis B virus DNA</subject><subject>Hepatitis B, Chronic - immunology</subject><subject>Hepatitis B, Chronic - pathology</subject><subject>Hepatitis B, Chronic - physiopathology</subject><subject>Hepatitis B, Chronic - virology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Liver - pathology</subject><subject>Liver Cirrhosis - pathology</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Occult hepatitis B virus infection</subject><subject>Polymerase chain reaction</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Viremia - virology</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkE1v1DAQhi0EotvCTwD5AoJDYMZxbOdUQVU-pJU4AGfLO3GoURIvtlOJf4-3u6LixGVmDs87M3oYe4bwBgHV26-1mMYIbV4BvgYQKBvzgG1QATSgJD5km7_IGTvP-ScAtNDLx-wMUbcGwWyY3cblR1N8mjlNYQnkJh7mvaPC48gj0ToVfuP3roQSMn_Pb0NaMw_L6KmEuNSJ002KNfkPdpj8UvIT9mh0U_ZPT_2Cff9w_e3qU7P98vHz1bttQ7LTpTGEWnQGlOjIS0E9KVTSdOSUdtCDd8MAzqPyfjeg7JTqSe-k0UJrdKJvL9jL4959ir9Wn4udQyY_TW7xcc1Wi1YK0YsKdkeQUsw5-dHuU5hd-m0R7MGsvTNrD9osoL0za03NPT8dWHezH-5TJ5UVeHECXK4Wx-QWCvmea1sD2KvKXR45X3XcBp9spqqK_BBSdWqHGP7zyh-UUJTx</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Komori, Masato</creator><creator>Yuki, Nobukazu</creator><creator>Nagaoka, Takayuki</creator><creator>Yamashiro, Masatoshi</creator><creator>Mochizuki, Kiyoshi</creator><creator>Kaneko, Akira</creator><creator>Yamamoto, Keiji</creator><creator>Hikiji, Kazumasa</creator><creator>Kato, Michio</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011201</creationdate><title>Long-term clinical impact of occult hepatitis B virus infection in chronic hepatitis B patients</title><author>Komori, Masato ; Yuki, Nobukazu ; Nagaoka, Takayuki ; Yamashiro, Masatoshi ; Mochizuki, Kiyoshi ; Kaneko, Akira ; Yamamoto, Keiji ; Hikiji, Kazumasa ; Kato, Michio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-8c172580625ce42c9c616485ca67a090eadd0ae16eebd145669c7b4872771a293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chronic hepatitis B</topic><topic>DNA, Viral - analysis</topic><topic>Female</topic><topic>Hepatitis B Antibodies - analysis</topic><topic>Hepatitis B Core Antigens - immunology</topic><topic>Hepatitis B Surface Antigens - analysis</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - isolation & purification</topic><topic>Hepatitis B virus DNA</topic><topic>Hepatitis B, Chronic - immunology</topic><topic>Hepatitis B, Chronic - pathology</topic><topic>Hepatitis B, Chronic - physiopathology</topic><topic>Hepatitis B, Chronic - virology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Liver - pathology</topic><topic>Liver Cirrhosis - pathology</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Occult hepatitis B virus infection</topic><topic>Polymerase chain reaction</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Viremia - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Komori, Masato</creatorcontrib><creatorcontrib>Yuki, Nobukazu</creatorcontrib><creatorcontrib>Nagaoka, Takayuki</creatorcontrib><creatorcontrib>Yamashiro, Masatoshi</creatorcontrib><creatorcontrib>Mochizuki, Kiyoshi</creatorcontrib><creatorcontrib>Kaneko, Akira</creatorcontrib><creatorcontrib>Yamamoto, Keiji</creatorcontrib><creatorcontrib>Hikiji, Kazumasa</creatorcontrib><creatorcontrib>Kato, Michio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Komori, Masato</au><au>Yuki, Nobukazu</au><au>Nagaoka, Takayuki</au><au>Yamashiro, Masatoshi</au><au>Mochizuki, Kiyoshi</au><au>Kaneko, Akira</au><au>Yamamoto, Keiji</au><au>Hikiji, Kazumasa</au><au>Kato, Michio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term clinical impact of occult hepatitis B virus infection in chronic hepatitis B patients</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>35</volume><issue>6</issue><spage>798</spage><epage>804</epage><pages>798-804</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><coden>JOHEEC</coden><abstract>Background
/
Aims
: Long-term clinical outcomes of occult hepatitis B virus (HBV) infection were studied.
Methods
: Fifteen chronic hepatitis B patients were monitored for a median of 4.4 years (range 0.9–15.3) after hepatitis B surface antigen (HBsAg) seroclearance. Serum HBV DNA was measured by real-time detection polymerase chain reaction. Thirteen patients underwent liver biopsies at the end of follow-up and liver histology was evaluated by Ishak score. Liver HBV DNA was also measured for 12 patients.
Results
: At the end of follow-up, HBV viremia was absent in 13 (87%) patients, and antibody titers to hepatitis B core antigen showed an inverse correlation with time from HBsAg seroclearance (
r=−0.554;
P=0.0040). However, all patients retained liver HBV DNA and tested positive for the covalently closed circular HBV DNA replicative intermediate. The hepatic HBV DNA loads had no relation to liver histology. Paired biopsies from 11 patients disclosed that each necroinflammatory score significantly improved after HBsAg seroclearance. Amelioration of liver fibrosis was also evident in eight (73%) patients (
P=0.0391 by signed rank test).
Conclusions: A long-standing but strongly suppressed HBV infection may confer histological amelioration after HBsAg seroclearance.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>11738108</pmid><doi>10.1016/S0168-8278(01)00214-8</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-8278 |
| ispartof | Journal of hepatology, 2001-12, Vol.35 (6), p.798-804 |
| issn | 0168-8278 1600-0641 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72342292 |
| source | ScienceDirect Freedom Collection |
| subjects | Adult Biological and medical sciences Chronic hepatitis B DNA, Viral - analysis Female Hepatitis B Antibodies - analysis Hepatitis B Core Antigens - immunology Hepatitis B Surface Antigens - analysis Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis B virus DNA Hepatitis B, Chronic - immunology Hepatitis B, Chronic - pathology Hepatitis B, Chronic - physiopathology Hepatitis B, Chronic - virology Human viral diseases Humans Infectious diseases Liver - pathology Liver Cirrhosis - pathology Longitudinal Studies Male Medical sciences Middle Aged Occult hepatitis B virus infection Polymerase chain reaction Viral diseases Viral hepatitis Viremia - virology |
| title | Long-term clinical impact of occult hepatitis B virus infection in chronic hepatitis B patients |
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