31P magnetic resonance spectroscopy in fibromyalgic muscle

Objective. To measure inorganic phosphate (Pi), phosphocreatine (PCr), ATP and phosphodiesters (PDE) in fibromyalgic muscle tissue by 31P magnetic resonance spectroscopy. Methods. A 1.5 Tesla scanner with a P 100 surface coil was used to examine 15 patients (mean age 49.9 ± 14.3 yr) with fibromyalgi...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2000-10, Vol.39 (10), p.1121-1125
Main Authors: Sprott, H., Rzanny, R., Reichenbach, J. R., Kaiser, W. A., Hein, G., Stein, G.
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Adult
ATP
Biological and medical sciences
Diseases of the osteoarticular system
Ethanolamines - metabolism
Female
Fibromyalgia
Fibromyalgia - metabolism
Glycerylphosphorylcholine - metabolism
Humans
Magnetic Resonance Spectroscopy
Male
Medical sciences
Middle Aged
Miscellaneous. Osteoarticular involvement in other diseases
Muscle, Skeletal - metabolism
Nucleosides - metabolism
Phosphate
Phosphates - metabolism
Phosphatidylethanolamines - metabolism
Phosphocreatine
Phosphocreatine - metabolism
Phosphodiesters
Phosphorus
Phosphorylcholine - metabolism
Reference Values
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Summary:Objective. To measure inorganic phosphate (Pi), phosphocreatine (PCr), ATP and phosphodiesters (PDE) in fibromyalgic muscle tissue by 31P magnetic resonance spectroscopy. Methods. A 1.5 Tesla scanner with a P 100 surface coil was used to examine 15 patients (mean age 49.9 ± 14.3 yr) with fibromyalgia, according to the American College of Rheumatology criteria, and 17 healthy controls (mean age 30.2 ± 5.8 yr). Results. Compared with the controls, there were increases in the levels of PDE (+22%, P = 0.032) and Pi (+19%, P = 0.019) in the spectra of fibromyalgia patients, but there was no difference in pH. Conclusion. The metabolic differences we found may have been related to weakness and fatigue in the fibromyalgia patients, but they do not fully explain the fibromyalgia symptoms.
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/39.10.1121