Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus

Previous studies have indicated that the autoimmune phenomenon might be caused by an imbalance of T helper cell (Th) cytokines. We measured the plasma concentrations of three novel proinflammatory cytokines interleukin (IL)-17, IL-18, IL-12 and a key Th2 cytokine IL-4 in patients with systemic lupus...

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Bibliographic Details
Published in:Lupus 2000-01, Vol.9 (8), p.589-593
Main Authors: Wong, C K, Ho, CY Y, Li, EK, Lam, CWK
Format: Article
Language:English
Subjects:
Adolescent
Adult
Asian Continental Ancestry Group
China - ethnology
Cytokines
Cytokines - blood
Disease
Female
Hong Kong
Hospitals
Humans
Inflammation
Interleukin-12 - blood
Interleukin-17 - blood
Interleukin-18 - blood
Interleukin-4 - blood
Interleukins - blood
Lupus
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - immunology
Lymphocytes
Male
Middle Aged
Pathogenesis
Plasma
Reference Values
Th2 Cells - immunology
Tumor necrosis factor-TNF
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Summary:Previous studies have indicated that the autoimmune phenomenon might be caused by an imbalance of T helper cell (Th) cytokines. We measured the plasma concentrations of three novel proinflammatory cytokines interleukin (IL)-17, IL-18, IL-12 and a key Th2 cytokine IL-4 in patients with systemic lupus erythematosus (SLE) and correlated the ratio of proin/Th2 cytokines with SLE disease activity index (SLEDAI). Plasma IL-12, IL-17, IL-18 and IL-4 concentrations of 36 SLE patients and 18 sex-and age-matched control subjects were measured by enzyme linked immunosorbent assay. All were significantly higher in SLE patients than control subjects (IL-12, mean± s.d. of 166.7± 84.5 vs 93.5± 39.2 pg/ml, P < 0.001; IL-17, 76.5± 45.7 vs 37.6± 35.3 pg/ml, P = 0.002; IL-18, 368.7± 199.5 vs 141.1± 47.1 pg/ml, P < 0.001; and IL-4, 27.1± 15.3 vs 17.3± 7.2 pg/ml, P < 0.05), and IL-18/IL-4 ratio correlated positively and significantly with SLEDAI score (r = 0.435, P = 0.006). We propose that SLE is characterized by an elevation of both Th1 and Th2 cytokines: the elevation of proinflammatory cytokine IL-12, IL-17 and IL-18 may trigger the inflammatory process in SLE and the elevation of IL-18/IL-4 ratio suggests an imbalance of cytokine profile to mediate the inflammatory response.
ISSN:0961-2033
1477-0962
DOI:10.1191/096120300678828703