Developmental aspects of androgen action

The formation of a testis from the indifferent gonad is the prelude to sequential steps in male sex differentiation orchestrated by time-dependent androgen biosynthesis and action. Information about the cellular and molecular mechanisms of androgen action can be obtained by the study of disorders of...

Full description

Saved in:
Bibliographic Details
Published in:Molecular and cellular endocrinology 2001-12, Vol.185 (1), p.33-41
Main Authors: Hughes, I.A., Lim, H.N., Martin, H., Mongan, N.P., Dovey, L., Ahmed, S.F., Hawkins, J.R.
Format: Article
Language:English
Subjects:
Androgen receptor
Androgen-responsive genes
Androgens - metabolism
Androgens - physiology
Co-regulators
Disorders of Sex Development - genetics
Gene Expression Regulation, Developmental
Humans
Male
Polyglutamine repeats
Receptors, Androgen - metabolism
Receptors, Androgen - physiology
Sex differentiation
Sex Differentiation - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The formation of a testis from the indifferent gonad is the prelude to sequential steps in male sex differentiation orchestrated by time-dependent androgen biosynthesis and action. Information about the cellular and molecular mechanisms of androgen action can be obtained by the study of disorders of sex differentiation in males. The pivotal role of the androgen receptor as a ligand-induced transcription factor is emphasised and preliminary studies are described which attempt to identify developmentally regulated androgen-responsive genes. That androgen action can be modulated by gene polymorphisms is illustrated by the influence of an androgen receptor polyglutamine repeat in the multi-factorial causation of less severe forms of male undermasculinisation.
ISSN:0303-7207
1872-8057
DOI:10.1016/S0303-7207(01)00622-0