Positron emission tomography with 2-[18F]fluoro-2-deoxy-D-glucose in oncology. Part II. The clinical value in detecting and staging primary tumours

The tumoral uptake of 2-[18F]fluoro-2-deoxy-D-glucose (18FdGlc) is based upon enhanced glycolysis. Positron-emission tomography (PET) using 18FdGlc provides the physiological and metabolic information. 18FdGlc PET has been used successfully for assessing primary tumours and metastases, prognosis, an...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2000-10, Vol.126 (10), p.560-574
Main Authors: AK, Ilknur, STOKKEL, Marcel P. M, PAUWELS, Ernest K. J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Breast Neoplasms - metabolism
Colorectal Neoplasms - metabolism
Female
Fluorodeoxyglucose F18 - metabolism
Head and Neck Neoplasms - metabolism
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lung Neoplasms - metabolism
Male
Medical sciences
Melanoma - metabolism
Miscellaneous. Technology
Neoplasm Staging
Neoplasms - diagnostic imaging
Neoplasms - metabolism
Ovarian Neoplasms - metabolism
Radionuclide investigations
Radiopharmaceuticals - metabolism
Skin Neoplasms - metabolism
Tomography, Emission-Computed - methods
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Summary:The tumoral uptake of 2-[18F]fluoro-2-deoxy-D-glucose (18FdGlc) is based upon enhanced glycolysis. Positron-emission tomography (PET) using 18FdGlc provides the physiological and metabolic information. 18FdGlc PET has been used successfully for assessing primary tumours and metastases, prognosis, and planning and for monitoring tumour therapy as well as for early detection of recurrent tumour growth. This review summarises the uptake mechanism of 18FdGlc in benign and malignant lesions, its relation to histopathology, and its clinical value for detecting and staging primary tumours.
ISSN:0171-5216
1432-1335
DOI:10.1007/PL00008466