Improved dysgammaglobulinaemia in congenital rubella syndrome after immunoglobulin therapy: correlation with CD154 expression

A boy with congenital rubella syndrome developed dysgammaglobulinaemia with elevated serum levels of IgM. CD154 was not induced on his peripheral blood mononuclear cells when rubella virus RNA was detected in his throat swabs and peripheral blood by reverse transcriptase polymerase chain reaction. F...

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Bibliographic Details
Published in:European journal of pediatrics 2000-10, Vol.159 (10), p.764-766
Main Authors: KAWAMURA, Nobuaki, OKAMURA, Akiko, FURUTA, Hirofumi, KATOW, Shigetaka, YAMADA, Masafumi, KOBAYASHI, Ichiro, OKANO, Motohiko, KOBAYASHI, Kunihiko, SAKIYAMA, Yukio
Format: Article
Language:English
Subjects:
Antibodies, Viral - blood
Biological and medical sciences
CD40 Ligand - immunology
Dysgammaglobulinemia - etiology
Dysgammaglobulinemia - immunology
Gene Expression Regulation
Humans
Immunoglobulin M
Immunoglobulins, Intravenous - administration & dosage
Immunoglobulins, Intravenous - therapeutic use
Infant
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Miscellaneous. Technology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral - genetics
Rubella Syndrome, Congenital - complications
Rubella Syndrome, Congenital - drug therapy
Rubella Syndrome, Congenital - immunology
Rubella virus - genetics
Rubella virus - immunology
Rubella virus - isolation & purification
Treatment Outcome
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Description
Summary:A boy with congenital rubella syndrome developed dysgammaglobulinaemia with elevated serum levels of IgM. CD154 was not induced on his peripheral blood mononuclear cells when rubella virus RNA was detected in his throat swabs and peripheral blood by reverse transcriptase polymerase chain reaction. Following intravenous immunoglobulin therapy, improvement of immunoglobulin abnormalities, disappearance of rubella virus and normalisation of CD154 expression were demonstrated. These findings implicate the efficacy of intravenous immunoglobulin therapy for dysgammaglobulinaemia in congenital rubella syndrome and a role of CD154 for a prolonged virus infection.
ISSN:0340-6199
1432-1076
DOI:10.1007/PL00008342