Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke

In animal models of cerebral ischemia, matrix metalloproteinase (MMP) expression was significantly increased and related to blood-brain barrier disruption, edema formation, and hemorrhagic transformation (HT). MMP inhibitors reduce HT after embolic ischemia in tissue-type plasminogen activator-treat...

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Bibliographic Details
Published in:Stroke (1970) 2001-12, Vol.32 (12), p.2762-2767
Main Authors: MONTANER, J, ALVAREZ-SABIN, J, MOLINA, C. A, ANGLES, A, ABILLEIRA, S, ARENILLAS, J, MONASTERIO, J
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Cerebral Hemorrhage - blood
Cerebral Hemorrhage - complications
Cerebral Hemorrhage - enzymology
Disease Progression
Enzyme-Linked Immunosorbent Assay
Female
Humans
Intracranial Embolism - blood
Intracranial Embolism - complications
Intracranial Embolism - enzymology
Logistic Models
Male
Matrix Metalloproteinase 2 - blood
Matrix Metalloproteinase 9 - blood
Medical sciences
Neurology
Predictive Value of Tests
Prospective Studies
Reference Values
Risk Assessment
Severity of Illness Index
Stroke - blood
Stroke - complications
Stroke - enzymology
Tomography, X-Ray Computed
Ultrasonography, Doppler, Transcranial
Vascular diseases and vascular malformations of the nervous system
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Summary:In animal models of cerebral ischemia, matrix metalloproteinase (MMP) expression was significantly increased and related to blood-brain barrier disruption, edema formation, and hemorrhagic transformation (HT). MMP inhibitors reduce HT after embolic ischemia in tissue-type plasminogen activator-treated animals. We aimed to determine the relationship between MMPs and HT after human ischemic stroke. Serial MMP-2 and MMP-9 determinations were performed by means of ELISA in 39 cardioembolic strokes in the middle cerebral artery territory. Hemorrhagic events were classified according to clinical and CT criteria (hemorrhagic infarction [HI] and parenchymal hematoma [PH]). HT was evaluated on CT at 48 hours (early HT) and again between day 5 and 7 (late HT). HT was present in 41% of the patients (43.75% early HI, 25% early PH and 31.25% late HI). MMP-2 values were within normal range and were unrelated to HT. Increased expression of MMP-9 (normal range
ISSN:0039-2499
1524-4628
DOI:10.1161/hs1201.99512