Evaluation of coagulation in pediatric bone marrow transplantation patients

• Published in: Pediatric transplantation 2001-12, Vol.5 (6), p.430-433
• Main Authors: Yenicesu, İdil, Uçkan, Duygu, Çetin, Mualla, Tuncer, A. M., Tezcan, İlhan, Gürgey, Aytemiz
• Format: Article
• Language: English
• Subjects: Adolescent; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood Coagulation; BMT; Bone Marrow Transplantation - physiology; Bone marrow, stem cells transplantation. Graft versus host reaction; Child; Child, Preschool; childhood; coagulation; Female; Fibrin Fibrinogen Degradation Products - analysis; Humans; Infant; Male; Medical sciences; Partial Thromboplastin Time; Prospective Studies; Protein C - analysis; Protein S - analysis; Transfusions. Complications. Transfusion reactions. Cell and gene therapy
• ISSN: 1397-3142; 1399-3046
• DOI: 10.1034/j.1399-3046.2001.t01-1-00036.x

: A hypercoagulable state is frequently described in adult patients undergoing bone marrow transplantation (BMT). In this study, the coagulation profile of 29 children was prospectively investigated in the pre‐ and post‐transplant period. A significant rise in the activated partial thromboplastin time (aPTT) values was detected on days 7 and 14 after transplantation. Moreover, an increase in the d‐dimer level was also notable, regardless of the clinical condition of the patients. The other coagulation parameters investigated (i.e. protein S, protein C, anti‐thrombin III, factor VIII, von Willebrand factor, and prothrombin time) remained essentially unchanged. However, hyper‐fibrinogenemia was observed in all patients with chronic myeloid leukemia (CML) (n=5) before and after transplantation. In summary, in the present study pediatric bone marrow transplantation patients did not show a hyper‐coagulable state after marrow infusion. However, a significant rise in PTT and d‐dimer values were noted.