Effect of selenium and vitamin E on antibody production by dairy cows vaccinated against Escherichia coli

Sixty clinically healthy Holstein cows were randomly assigned to one of four groups according to their age and parity and vaccinated in late pregnancy (day 190) with a multivalent vaccine against Escherichia coli. The 15 cows in the first group (SeE) were injeded intramuscularly with a solution of s...

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Bibliographic Details
Published in:Veterinary record 2001-11, Vol.149 (21), p.643-646
Main Authors: Panousis, N., Karatzias, H., Roubies, N., Papasteriadis, A., Frydas, S.
Format: Article
Language:English
Subjects:
Animals
Antibody Formation
Cattle - immunology
Cattle Diseases - microbiology
Cattle Diseases - prevention & control
Dairying
Enzyme-Linked Immunosorbent Assay
Escherichia coli Infections - prevention & control
Escherichia coli Infections - veterinary
Female
Selenium - pharmacology
Vaccination - veterinary
Vitamin E - pharmacology
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Summary:Sixty clinically healthy Holstein cows were randomly assigned to one of four groups according to their age and parity and vaccinated in late pregnancy (day 190) with a multivalent vaccine against Escherichia coli. The 15 cows in the first group (SeE) were injeded intramuscularly with a solution of sodium selenite (0.1 mg Se/kg bodyweight) and vitamin E (α-tocopherol acetate, 8 U/kg bodyweight), the cows in the second group (Se) received only selenium and the cows in the third group (E) received only vitamin E at the same doses and by the same route of administration; the cows in the fourth group were used as controls. The vaccination and the injections of selenium and vitamin E were repeated 42 days later. The concentration of selenium in whole blood and of vitamin E in serum was determined by fluorometric methods. Specific antibody titres against E coli were determined in serum samples by ELISA. The results showed that the injection of selenium either alone or in combination with vitamin E significantly improved the production of specific antibodies against E coli, and that the production of specific antibodies was greater after the administration of selenium alone.
ISSN:0042-4900
2042-7670
DOI:10.1136/vr.149.21.643