A Field Guide to Foldamers

A foldamer is any oligomer that folds into a conformationally ordered state in solution, the structures of which are stabilized by a collection of noncovalent interactions between nonadjacent monomer units. A overview of foldamers is presented, focusing on peptidomimetic, single-stranded abiotic, nu...

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Bibliographic Details
Published in:Chemical reviews 2001-12, Vol.101 (12), p.3893-4012
Main Authors: Hill, David J, Mio, Matthew J, Prince, Ryan B, Hughes, Thomas S, Moore, Jeffrey S
Format: Article
Language:English
Subjects:
Biopolymers - chemistry
Chemical reactions
Models, Molecular
Molecular Conformation
Molecular Mimicry
Oligonucleotides - chemistry
Peptides - chemistry
Polymers
Polymers - chemical synthesis
Polymers - chemistry
Protein Folding
Protein Structure, Secondary
Thermodynamics
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Summary:A foldamer is any oligomer that folds into a conformationally ordered state in solution, the structures of which are stabilized by a collection of noncovalent interactions between nonadjacent monomer units. A overview of foldamers is presented, focusing on peptidomimetic, single-stranded abiotic, nucleotidomimetic, and multistranded abiotic foldamers.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr990120t